Neuro Oncol · 2021

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW.

Show affiliations
  • Louis DNDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Perry ADepartment of Pathology, University of California San Francisco, San Francisco, California, USA.
  • Wesseling PDepartment of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, the Netherlands.
  • Brat DJDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Cree IAInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Figarella-Branger DService d'Anatomie Pathologique et de Neuropathologie, APHM, CNRS, Institut de Neurophysiopathologie, Hôpital de la Timone, Aix-Marseille University, Marseille, France.
  • Hawkins CDepartment of Paediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Ng HKDepartment of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong, China.
  • Pfister SMHopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Division of Pediatric Neurooncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), and Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.
  • Reifenberger GInstitute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University Düsseldorf, and German Cancer Consortium (DKTK) Partner Site Essen/Düsseldorf, Düsseldorf, Germany.
  • Soffietti RDepartment of Neurology and Neuro-Oncology, University of Turin Medical School, Turin, Italy.
  • von Deimling ADepartment of Neuropathology, Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany.
  • Ellison DWDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
62 read9 want to readRigor 3.0Novelty 3.1Impact 2.9Reprod. 3.2

Most-cited papers citing this

  • Nat Metab · 2026 · cited by 1
  • Neuro Oncol · 2026 · cited by 1
  • Appl Psychophysiol Biofeedback · 2026
  • Cell Death Dis · 2026
  • Jpn J Radiol · 2026

Log in to like, log, and share thoughts on this paper.

Discussion

Share your thoughts above to start a thread. Constructive feedback only — reply to and like others’ posts.

0

Ines Brown

Rigor 2/5Novelty 4/5Impact 5/5Reprod. 2/5

Interesting idea, small sample.

0

Jonas Brown

Rigor 1/5Novelty 2/5Impact 3/5Reprod. 2/5

Important contribution to the field.

0

Pablo Silva

Rigor 1/5Novelty 4/5Impact 4/5Reprod. 2/5

Nice but incremental.

0

Omar Lee

Rigor 3/5Novelty 2/5Impact 1/5Reprod. 4/5

Important contribution to the field.

0

Noor Brown

Rigor 5/5Novelty 2/5Impact 2/5Reprod. 3/5

Solid methods, convincing results.

0

Omar Wang

Rigor 3/5Novelty 2/5Impact 5/5Reprod. 5/5

Great figures and clear story.

0

Tariq Silva

Rigor 3/5Novelty 3/5Impact 2/5Reprod. 1/5

Solid methods, convincing results.

0

Nadia Nguyen

Rigor 4/5Novelty 5/5Impact 5/5Reprod. 3/5

Replication is unclear to me.

0

Liam Rossi

Rigor 3/5Novelty 2/5Impact 1/5Reprod. 5/5

Great figures and clear story.

0

Jonas Rossi

Rigor 1/5Novelty 1/5Impact 2/5Reprod. 1/5

Important contribution to the field.

0

Ravi Rossi

Rigor 3/5Novelty 4/5Impact 1/5Reprod. 1/5

Solid methods, convincing results.

0

Eva Kim

Rigor 2/5Novelty 5/5Impact 3/5Reprod. 4/5

Nice but incremental.

0

Lena Mueller

Rigor 3/5Novelty 3/5Impact 1/5Reprod. 4/5

Important contribution to the field.