Science · 2018
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
Chen JS, Ma E, Harrington LB, Da Costa M, Tian X, Palefsky JM, Doudna JA.
Show affiliations
- Chen JS — Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
- Ma E — Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
- Harrington LB — Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
- Da Costa M — Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
- Tian X — Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
- Palefsky JM — Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
- Doudna JA — Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. doudna@berkeley.edu.
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