Nat Rev Cancer · 2020

A framework for advancing our understanding of cancer-associated fibroblasts

Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z.

Show affiliations
  • Sahai E — The Francis Crick Institute, London, UK. erik.sahai@crick.ac.uk.
  • Astsaturov I — Marvin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA, USA.
  • Cukierman E — Cancer Biology Program, Marvin & Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA, USA.
  • DeNardo DG — Division of Oncology, Washington University Medical School, St Louis, MO, USA.
  • Egeblad M — Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Evans RM — Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
  • Fearon D — Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Greten FR — Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany.
  • Hingorani SR — Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Hunter T — Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
  • Hynes RO — Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Jain RK — Edwin L Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Janowitz T — Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Jorgensen C — Cancer Research UK Manchester Institute, University of Manchester, Nether Alderley, UK.
  • Kimmelman AC — Department of Radiation Oncology, Perlmutter Cancer Center, New York University Medical Center, New York, NY, USA.
  • Kolonin MG — Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Houston, TX, USA.
  • Maki RG — Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Powers RS — Department of Pathology, Stony Brook University, Stony Brook, NY, USA.
  • Puré E — Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Ramirez DC — Zucker School of Medicine at Hofstra/Northwell Health System, New York, NY, USA.
  • Scherz-Shouval R — Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
  • Sherman MH — Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR, USA.
  • Stewart S — Department of Cell Biology and Physiology, Department of Medicine, ICCE Institute, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA.
  • Tlsty TD — UCSF Helen Diller Comprehensive Cancer Center, San Francisco, CA, USA.
  • Tuveson DA — Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Watt FM — Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, London, UK.
  • Weaver V — Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.
  • Weeraratna AT — Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Werb Z — Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.
79 read15 want to readRigor 3.1Novelty 2.7Impact 3.0Reprod. 2.7

Most-cited papers citing this

  • Gut · 2026 · cited by 4
  • Signal Transduct Target Ther · 2026 · cited by 2
  • Int Immunol · 2026 · cited by 1
  • Cancer Discov · 2026 · cited by 1
  • Apoptosis · 2026 · cited by 1

Log in to like, log, and share thoughts on this paper.

Discussion

Share your thoughts above to start a thread. Constructive feedback only — reply to and like others’ posts.

0

Omar Rossi

Rigor 5/5Novelty 5/5Impact 2/5Reprod. 1/5

Interesting idea, small sample.

0

Lena Patel

Rigor 1/5Novelty 5/5Impact 3/5Reprod. 5/5

Nice but incremental.

0

Hugo Khan

Rigor 2/5Novelty 2/5Impact 5/5Reprod. 2/5

Nice but incremental.

0

Tom Rossi

Rigor 3/5Novelty 3/5Impact 5/5Reprod. 4/5

Replication is unclear to me.

0

Ken Kim

Rigor 4/5Novelty 1/5Impact 5/5Reprod. 4/5

Replication is unclear to me.

0

Yuki Patel

Rigor 1/5Novelty 5/5Impact 4/5Reprod. 4/5

Interesting idea, small sample.

0

Nadia Garcia

Rigor 2/5Novelty 1/5Impact 1/5Reprod. 5/5

Interesting idea, small sample.

0

Tom Smith

Rigor 5/5Novelty 2/5Impact 3/5Reprod. 4/5

Important contribution to the field.

0

Sam Lee

Rigor 3/5Novelty 2/5Impact 5/5Reprod. 1/5

Great figures and clear story.

0

Lena Sato

Rigor 4/5Novelty 4/5Impact 4/5Reprod. 4/5

Solid methods, convincing results.

0

Tom Sato

Rigor 1/5Novelty 2/5Impact 1/5Reprod. 4/5

Important contribution to the field.

0

Yuki Brown

Rigor 2/5Novelty 1/5Impact 2/5Reprod. 3/5

Great figures and clear story.

0

Pablo Brown

Rigor 4/5Novelty 2/5Impact 2/5Reprod. 2/5

Great figures and clear story.

0

Hugo Park

Rigor 5/5Novelty 3/5Impact 4/5Reprod. 1/5

Nice but incremental.

0

Tom Park

Rigor 5/5Novelty 2/5Impact 4/5Reprod. 3/5

Solid methods, convincing results.

0

Ravi Park

Rigor 2/5Novelty 5/5Impact 3/5Reprod. 3/5

Solid methods, convincing results.

0

Ravi Smith

Rigor 4/5Novelty 5/5Impact 4/5Reprod. 3/5

Nice but incremental.

0

Hugo Smith

Rigor 3/5Novelty 2/5Impact 4/5Reprod. 1/5

Interesting idea, small sample.