Nat Rev Cancer · 2020

A framework for advancing our understanding of cancer-associated fibroblasts

Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z.

Show affiliations
  • Sahai EThe Francis Crick Institute, London, UK. erik.sahai@crick.ac.uk.
  • Astsaturov IMarvin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA, USA.
  • Cukierman ECancer Biology Program, Marvin & Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA, USA.
  • DeNardo DGDivision of Oncology, Washington University Medical School, St Louis, MO, USA.
  • Egeblad MCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Evans RMGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
  • Fearon DCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Greten FRInstitute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany.
  • Hingorani SRFred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Hunter TMolecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
  • Hynes ROKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Jain RKEdwin L Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Janowitz TCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Jorgensen CCancer Research UK Manchester Institute, University of Manchester, Nether Alderley, UK.
  • Kimmelman ACDepartment of Radiation Oncology, Perlmutter Cancer Center, New York University Medical Center, New York, NY, USA.
  • Kolonin MGBrown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Houston, TX, USA.
  • Maki RGCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Powers RSDepartment of Pathology, Stony Brook University, Stony Brook, NY, USA.
  • Puré EDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Ramirez DCZucker School of Medicine at Hofstra/Northwell Health System, New York, NY, USA.
  • Scherz-Shouval RDepartment of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
  • Sherman MHDepartment of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR, USA.
  • Stewart SDepartment of Cell Biology and Physiology, Department of Medicine, ICCE Institute, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA.
  • Tlsty TDUCSF Helen Diller Comprehensive Cancer Center, San Francisco, CA, USA.
  • Tuveson DACold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Watt FMCentre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, London, UK.
  • Weaver VCenter for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.
  • Weeraratna ATSidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Werb ZDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, USA.
79 read15 want to readRigor 3.1Novelty 2.7Impact 3.0Reprod. 2.7

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Discussion

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0

Omar Rossi

Rigor 5/5Novelty 5/5Impact 2/5Reprod. 1/5

Interesting idea, small sample.

0

Lena Patel

Rigor 1/5Novelty 5/5Impact 3/5Reprod. 5/5

Nice but incremental.

0

Hugo Khan

Rigor 2/5Novelty 2/5Impact 5/5Reprod. 2/5

Nice but incremental.

0

Tom Rossi

Rigor 3/5Novelty 3/5Impact 5/5Reprod. 4/5

Replication is unclear to me.

0

Ken Kim

Rigor 4/5Novelty 1/5Impact 5/5Reprod. 4/5

Replication is unclear to me.

0

Yuki Patel

Rigor 1/5Novelty 5/5Impact 4/5Reprod. 4/5

Interesting idea, small sample.

0

Nadia Garcia

Rigor 2/5Novelty 1/5Impact 1/5Reprod. 5/5

Interesting idea, small sample.

0

Tom Smith

Rigor 5/5Novelty 2/5Impact 3/5Reprod. 4/5

Important contribution to the field.

0

Sam Lee

Rigor 3/5Novelty 2/5Impact 5/5Reprod. 1/5

Great figures and clear story.

0

Lena Sato

Rigor 4/5Novelty 4/5Impact 4/5Reprod. 4/5

Solid methods, convincing results.

0

Tom Sato

Rigor 1/5Novelty 2/5Impact 1/5Reprod. 4/5

Important contribution to the field.

0

Yuki Brown

Rigor 2/5Novelty 1/5Impact 2/5Reprod. 3/5

Great figures and clear story.

0

Pablo Brown

Rigor 4/5Novelty 2/5Impact 2/5Reprod. 2/5

Great figures and clear story.

0

Hugo Park

Rigor 5/5Novelty 3/5Impact 4/5Reprod. 1/5

Nice but incremental.

0

Tom Park

Rigor 5/5Novelty 2/5Impact 4/5Reprod. 3/5

Solid methods, convincing results.

0

Ravi Park

Rigor 2/5Novelty 5/5Impact 3/5Reprod. 3/5

Solid methods, convincing results.

0

Ravi Smith

Rigor 4/5Novelty 5/5Impact 4/5Reprod. 3/5

Nice but incremental.

0

Hugo Smith

Rigor 3/5Novelty 2/5Impact 4/5Reprod. 1/5

Interesting idea, small sample.