Nat Genet · 2019

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujić-Čomić H, Frosch MP, Thonberg H, Maier W, Roshchupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Andre Uitterlinden AG, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O'Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, Quinn JF, Sacchinelli E, Raj A, Spalletta G, Raskind M, Caltagirone C, Bossù P, Orfei MD, Reisberg B, Clarke R, Reitz C, Smith AD, Ringman JM, Warden D, Roberson ED, Wilcock G, Rogaeva E, Bruni AC, Rosen HJ, Gallo M, Rosenberg RN, Ben-Shlomo Y, Sager MA, Mecocci P, Saykin AJ, Pastor P, Cuccaro ML, Vance JM, Schneider JA, Schneider LS, Slifer S, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tang M, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Saba Y, Pilotto A, Bullido MJ, Peters O, Crane PK, Bennett D, Bosco P, Coto E, Boccardi V, De Jager PL, Lleo A, Warner N, Lopez OL, Ingelsson M, Deloukas P, Cruchaga C, Graff C, Gwilliam R, Fornage M, Goate AM, Sanchez-Juan P, Kehoe PG, Amin N, Ertekin-Taner N, Berr C, Debette S, Debette S, Love S, Launer LJ, Younkin SG, Dartigues JF, Corcoran C, Ikram MA, Dickson DW, Nicolas G, Campion D, Tschanz J, Schmidt H, Hakonarson H, Clarimon J, Munger R, Schmidt R, Farrer LA, Van Broeckhoven C, C O'Donovan M, DeStefano AL, Jones L, Haines JL, Deleuze JF, Owen MJ, Gudnason V, Mayeux R, Escott-Price V, Psaty BM, Ramirez A, Wang LS, Ruiz A, van Duijn CM, Holmans PA, Seshadri S, Williams J, Amouyel P, Schellenberg GD, Lambert JC, Pericak-Vance MA, Alzheimer Disease Genetics Consortium (ADGC),, European Alzheimer’s Disease Initiative (EADI),, Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE),, Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES),.

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Kunkle BW — John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. bkunkle@miami.edu.
Grenier-Boley B — Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
Sims R — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Bis JC — Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Damotte V — Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
Naj AC — Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Boland A — Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Vronskaya M — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
van der Lee SJ — Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Amlie-Wolf A — Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Bellenguez C — Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
Frizatti A — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Chouraki V — Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
Martin ER — John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Sleegers K — Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.
Badarinarayan N — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Jakobsdottir J — Icelandic Heart Association, Kopavogur, Iceland.
Hamilton-Nelson KL — John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Moreno-Grau S — Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
Olaso R — Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Raybould R — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Chen Y — Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Kuzma AB — Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Hiltunen M — Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Morgan T — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Ahmad S — Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Vardarajan BN — Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
Epelbaum J — UMR 894, Center for Psychiatry and Neuroscience, Inserm, Université Paris Descartes, Paris, France.
Hoffmann P — Institute of Human Genetics, University of Bonn, Bonn, Germany.
Boada M — Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
Beecham GW — John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Garnier JG — Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Harold D — School of Biotechnology, Dublin City University, Dublin, Ireland.
Fitzpatrick AL — Department of Family Medicine, University of Washington, Seattle, WA, USA.
Valladares O — Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Moutet ML — Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Gerrish A — Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Smith AV — Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Qu L — Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Bacq D — Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Denning N — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Jian X — Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA.
Zhao Y — Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Del Zompo M — Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Fox NC — Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Choi SH — Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
Mateo I — Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain.
Hughes JT — Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Adams HH — Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Malamon J — Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Sanchez-Garcia F — Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Patel Y — Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Brody JA — Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Dombroski BA — Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Naranjo MCD — Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Daniilidou M — Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Eiriksdottir G — Icelandic Heart Association, Kopavogur, Iceland.
Mukherjee S — Department of Medicine, University of Washington, Seattle, WA, USA.
Wallon D — Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France.
Uphill J — Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK.
Aspelund T — Icelandic Heart Association, Kopavogur, Iceland.
Cantwell LB — Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Garzia F — Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Galimberti D — Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.
Hofer E — Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria.
Butkiewicz M — Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Fin B — Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Scarpini E — Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.
Sarnowski C — Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Bush WS — Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Meslage S — Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Kornhuber J — Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany.
White CC — Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Song Y — Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Barber RC — Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
Engelborghs S — Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Sordon S — Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
Voijnovic D — Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Adams PM — Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Vandenberghe R — Laboratory for Cognitive Neurology, Department of Neurology, University Hospital and University of Leuven, Leuven, Belgium.
Mayhaus M — Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
Cupples LA — Framingham Heart Study, Framingham, MA, USA.
Albert MS — Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
De Deyn PP — Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Gu W — Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
Himali JJ — Framingham Heart Study, Framingham, MA, USA.
Beekly D — National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA.
Squassina A — Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Hartmann AM — Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany.
Orellana A — Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
Blacker D — Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Rodriguez-Rodriguez E — Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain.
Lovestone S — Department of Psychiatry, University of Oxford, Oxford, UK.
Garcia ME — Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
Doody RS — Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA.
Munoz-Fernadez C — Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Sussams R — Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
Lin H — Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Fairchild TJ — Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, TX, USA.
Benito YA — Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Holmes C — Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
Karamujić-Čomić H — Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Frosch MP — C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, MA, USA.
Thonberg H — Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.
Maier W — German Center for Neurodegenerative Diseases, Bonn, Germany.
Roshchupkin G — Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Ghetti B — Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA.
Giedraitis V — Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Kawalia A — Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
Li S — Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Huebinger RM — Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kilander L — Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Moebus S — Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
Hernández I — Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
Kamboh MI — Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Brundin R — Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Turton J — Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Yang Q — Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Katz MJ — Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Concari L — Section of Neuroscience, DIMEC-University of Parma, Parma, Italy.
Lord J — Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Beiser AS — Framingham Heart Study, Framingham, MA, USA.
Keene CD — Department of Pathology, University of Washington, Seattle, WA, USA.
Helisalmi S — Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Kloszewska I — Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland.
Kukull WA — Department of Epidemiology, University of Washington, Seattle, WA, USA.
Koivisto AM — Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Lynch A — Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.
Tarraga L — Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
Larson EB — Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Haapasalo A — A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Lawlor B — Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.
Mosley TH — Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, MS, USA.
Lipton RB — Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Solfrizzi V — Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unity, University of Bari, Bari, Italy.
Gill M — Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.
Longstreth WT Jr — Department of Epidemiology, University of Washington, Seattle, WA, USA.
Montine TJ — Department of Pathology, University of Washington, Seattle, WA, USA.
Frisardi V — Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy.
Diez-Fairen M — Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.
Rivadeneira F — Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Petersen RC — Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Deramecourt V — CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France.
Alvarez I — Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.
Salani F — Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
Ciaramella A — Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
Boerwinkle E — School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
Reiman EM — Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
Fievet N — Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
Rotter JI — Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Reisch JS — Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hanon O — University Paris Descartes, EA 4468, AP-HP, Geriatrics Department, Hôpital Broca, Paris, France.
Cupidi C — Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
Andre Uitterlinden AG — Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Royall DR — Departments of Psychiatry, Medicine, Family & Community Medicine, South Texas Veterans Health Administration Geriatric Research Education & Clinical Center (GRECC), UT Health Science Center at San Antonio, San Antonio, TX, USA.
Dufouil C — University of Bordeaux, Inserm 1219, Bordeaux, France.
Maletta RG — Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
de Rojas I — Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
Sano M — Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Brice A — Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.
Cecchetti R — Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
George-Hyslop PS — Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Ritchie K — Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.
Tsolaki M — Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Tsuang DW — VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA.
Dubois B — Institut de la Mémoire et de la Maladie d'Alzheimer and Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.
Craig D — Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Wu CK — Departments of Neurology, Pharmacology & Neuroscience, Texas Tech University Health Science Center, Lubbock, TX, USA.
Soininen H — Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Avramidou D — Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Albin RL — Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
Fratiglioni L — Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Germanou A — Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Apostolova LG — Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Keller L — Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Koutroumani M — Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Arnold SE — Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Panza F — Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy.
Gkatzima O — Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Asthana S — Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, WI, USA.
Hannequin D — Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Whitehead P — John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Atwood CS — Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
Caffarra P — Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
Hampel H — AXA Research Fund & Sorbonne University Chair, Paris, France.
Quintela I — Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain.
Carracedo Á — Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain.
Lannfelt L — Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Rubinsztein DC — Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Barnes LL — Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Pasquier F — CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France.
Frölich L — Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
Barral S — Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
McGuinness B — Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Beach TG — Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, AZ, USA.
Johnston JA — Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Becker JT — Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Passmore P — Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Bigio EH — Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Schott JM — Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Bird TD — Department of Neurology, University of Washington, Seattle, WA, USA.
Warren JD — Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Boeve BF — Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Lupton MK — Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Bowen JD — Swedish Medical Center, Seattle, WA, USA.
Proitsi P — Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Boxer A — Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Powell JF — Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Burke JR — Department of Neurology, Duke University, Durham, NC, USA.
Kauwe JSK — Departments of Biology, Brigham Young University, Provo, UT, USA.
Burns JM — University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA.
Mancuso M — Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy.
Buxbaum JD — Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bonuccelli U — Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy.
Cairns NJ — Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.
McQuillin A — Division of Psychiatry, University College London, London, UK.
Cao C — USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
Livingston G — Division of Psychiatry, University College London, London, UK.
Carlson CS — Department of Medicine, University of Wisconsin, Madison, WI, USA.
Bass NJ — Division of Psychiatry, University College London, London, UK.
Carlsson CM — Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Hardy J — Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.
Carney RM — Mental Health & Behavioral Science Service, Bruce W. Carter VA Medical Center, Miami, FL, USA.
Bras J — UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Carrasquillo MM — Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Guerreiro R — UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Allen M — Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Chui HC — Department of Neurology, University of Southern California, Los Angeles, CA, USA.
Fisher E — Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Masullo C — Department of Neurology, Catholic University of Rome, Rome, Italy.
Crocco EA — Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.
DeCarli C — Department of Neurology, University of California, Davis, Sacramento, CA, USA.
Bisceglio G — Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Dick M — Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Ma L — Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Duara R — Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA.
Graff-Radford NR — Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Evans DA — Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
Hodges A — Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Faber KM — Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Scherer M — Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Fallon KB — Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Riemenschneider M — Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
Fardo DW — Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA.
Heun R — Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Farlow MR — Department of Neurology, Indiana University, Indianapolis, IN, USA.
Kölsch H — Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Ferris S — Department of Psychiatry, New York University, New York, NY, USA.
Leber M — Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
Foroud TM — Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Heuser I — Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.
Galasko DR — Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Giegling I — Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany.
Gearing M — Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.
Hüll M — Department of Psychiatry, University of Freiburg, Freiburg, Germany.
Geschwind DH — Neurogenetics Program, University of California, Los Angeles, Los Angeles, CA, USA.
Gilbert JR — John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Morris J — Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Green RC — Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Mayo K — Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Growdon JH — Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Feulner T — Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
Hamilton RL — Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, PA, USA.
Harrell LE — Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Drichel D — Cologne Center for Genomics, University of Cologne, Cologne, Germany.
Honig LS — Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
Cushion TD — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Huentelman MJ — Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
Hollingworth P — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Hulette CM — Department of Pathology, Duke University, Durham, NC, USA.
Hyman BT — Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Marshall R — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Jarvik GP — Department of Genome Sciences, University of Washington, Seattle, WA, USA.
Meggy A — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Abner E — Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, KY, USA.
Menzies GE — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Jin LW — Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
Leonenko G — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Real LM — Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
Jun GR — Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Baldwin CT — Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Grozeva D — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Karydas A — Swedish Medical Center, Seattle, WA, USA.
Russo G — Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland.
Kaye JA — Department of Neurology, Oregon Health &Science University, Portland, OR, USA.
Kim R — Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
Jessen F — German Center for Neurodegenerative Diseases, Bonn, Germany.
Kowall NW — Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
Vellas B — Inserm U558, University of Toulouse, Toulouse, France.
Kramer JH — Department of Neuropsychology, University of California San Francisco, San Francisco, CA, USA.
Vardy E — Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.
LaFerla FM — Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA.
Jöckel KH — Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
Lah JJ — Department of Neurology, Emory University, Atlanta, GA, USA.
Dichgans M — Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.
Leverenz JB — Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA.
Mann D — Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Levey AI — Department of Neurology, Emory University, Atlanta, GA, USA.
Pickering-Brown S — Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Lieberman AP — Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Klopp N — Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Munich, Germany.
Lunetta KL — Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Wichmann HE — Helmholtz Center Munich, Institute of Epidemiology, Neuherberg, Munich, Germany.
Lyketsos CG — Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
Morgan K — Human Genetics, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK.
Marson DC — Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Brown K — Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Martiniuk F — Department of Medicine-Pulmonary, New York University, New York, NY, USA.
Medway C — Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Mash DC — Department of Neurology, University of Miami, Miami, FL, USA.
Nöthen MM — Institute of Human Genetics, University of Bonn, Bonn, Germany.
Masliah E — Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Hooper NM — Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
McCormick WC — Department of Medicine, University of Washington, Seattle, WA, USA.
Daniele A — Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy.
McCurry SM — School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, WA, USA.
Bayer A — Institute of Primary Care and Public Health, Cardiff University, University Hospital of Wales, Cardiff, UK.
McDavid AN — USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
Gallacher J — Department of Psychiatry, University of Oxford, Oxford, UK.
McKee AC — Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
van den Bussche H — Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Mesulam M — Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Brayne C — Cambridge Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Miller BL — Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
Riedel-Heller S — Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
Miller CA — Department of Pathology, University of Southern California, Los Angeles, CA, USA.
Miller JW — Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA.
Al-Chalabi A — Institute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK.
Morris JC — Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.
Shaw CE — Institute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK.
Myers AJ — Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.
Wiltfang J — Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.
O'Bryant S — Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
Olichney JM — Department of Neurology, University of California, Davis, Sacramento, CA, USA.
Alvarez V — Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain.
Parisi JE — Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Singleton AB — Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Paulson HL — Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
Collinge J — Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK.
Perry WR — John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Mead S — Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK.
Peskind E — Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Cribbs DH — Department of Neurology, University of California, Irvine, Irvine, CA, USA.
Rossor M — Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Pierce A — Department of Neurology, University of California, Irvine, Irvine, CA, USA.
Ryan NS — Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK.
Poon WW — Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Nacmias B — Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Potter H — Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA.
Sorbi S — Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Quinn JF — Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Sacchinelli E — Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
Raj A — USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
Spalletta G — Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Raskind M — Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Caltagirone C — Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Bossù P — Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
Orfei MD — Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Reisberg B — Department of Psychiatry, New York University, New York, NY, USA.
Clarke R — Oxford Healthy Aging Project, Clinical Trial Service Unit, University of Oxford, Oxford, UK.
Reitz C — Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
Smith AD — Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.
Ringman JM — Department of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, Los Angeles, CA, USA.
Warden D — Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.
Roberson ED — Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Wilcock G — Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.
Rogaeva E — Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
Bruni AC — Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
Rosen HJ — Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Gallo M — Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
Rosenberg RN — Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ben-Shlomo Y — Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Sager MA — Department of Medicine, University of Wisconsin, Madison, WI, USA.
Mecocci P — Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
Saykin AJ — Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Pastor P — Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.
Cuccaro ML — John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Vance JM — John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Schneider JA — Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Schneider LS — Department of Neurology, University of Southern California, Los Angeles, CA, USA.
Slifer S — John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Seeley WW — Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Smith AG — USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
Sonnen JA — Department of Pathology, University of Washington, Seattle, WA, USA.
Spina S — Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA.
Stern RA — Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
Swerdlow RH — University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA.
Tang M — Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Tanzi RE — Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Trojanowski JQ — Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Troncoso JC — Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Van Deerlin VM — Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Van Eldik LJ — Sanders-Brown Center on Aging, Department of Neuroscience, University of Kentucky, Lexington, KY, USA.
Vinters HV — Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
Vonsattel JP — Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, NY, USA.
Weintraub S — Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Welsh-Bohmer KA — Department of Neurology, Duke University, Durham, NC, USA.
Wilhelmsen KC — Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Williamson J — Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
Wingo TS — Department of Neurology, Emory University, Atlanta, GA, USA.
Woltjer RL — Department of Pathology, Oregon Health & Science University, Portland, OR, USA.
Wright CB — National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Yu CE — Department of Medicine, University of Washington, Seattle, WA, USA.
Yu L — Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Saba Y — Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.
Pilotto A — Gerontology and Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Bullido MJ — Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.
Peters O — Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.
Crane PK — Department of Medicine, University of Washington, Seattle, WA, USA.
Bennett D — Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Bosco P — Instituto di Ricovero e Cura a Carattere Scientifico, Associazione Oasi Maria Santissima Srl, Troina, Italy.
Coto E — Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain.
Boccardi V — Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
De Jager PL — Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
Lleo A — Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.
Warner N — Somerset Partnership NHS Trust, Somerset, UK.
Lopez OL — Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Ingelsson M — Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Deloukas P — The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
Cruchaga C — Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Graff C — Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.
Gwilliam R — The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
Fornage M — Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA.
Goate AM — Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sanchez-Juan P — Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain.
Kehoe PG — University of Bristol Medical School, Learning & Research level 2, Southmead Hospital, Bristol, UK.
Amin N — Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Ertekin-Taner N — Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Berr C — Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.
Debette S — Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.
Debette S — Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.
Love S — University of Bristol Medical School, Learning & Research level 2, Southmead Hospital, Bristol, UK.
Launer LJ — Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
Younkin SG — Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Dartigues JF — Memory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France.
Corcoran C — Utah State University, Logan, UT, USA.
Ikram MA — Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Dickson DW — Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Nicolas G — Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France.
Campion D — Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France.
Tschanz J — Utah State University, Logan, UT, USA.
Schmidt H — Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.
Hakonarson H — Center for Applied Genomics, Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Clarimon J — Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.
Munger R — Utah State University, Logan, UT, USA.
Schmidt R — Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria.
Farrer LA — Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
Van Broeckhoven C — Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.
C O'Donovan M — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
DeStefano AL — Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
Jones L — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Haines JL — Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Deleuze JF — Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Owen MJ — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Gudnason V — Icelandic Heart Association, Kopavogur, Iceland.
Mayeux R — Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
Escott-Price V — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Psaty BM — Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Ramirez A — Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
Wang LS — Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Ruiz A — Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
van Duijn CM — Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Holmans PA — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Seshadri S — Framingham Heart Study, Framingham, MA, USA.
Williams J — Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Amouyel P — Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
Schellenberg GD — Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Lambert JC — Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. jean-charles.lambert@pasteur-lille.fr.
Pericak-Vance MA — John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. mpericak@miami.edu.