Cell · 2016

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, Challis C, Schretter CE, Rocha S, Gradinaru V, Chesselet MF, Keshavarzian A, Shannon KM, Krajmalnik-Brown R, Wittung-Stafshede P, Knight R, Mazmanian SK.

Show affiliations
  • Sampson TR — Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: trsamps@caltech.edu.
  • Debelius JW — Department of Pediatrics, University of California, San Diego, San Diego, CA 92110, USA.
  • Thron T — Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Janssen S — Department of Pediatrics, University of California, San Diego, San Diego, CA 92110, USA.
  • Shastri GG — Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Ilhan ZE — Swette Center for Environmental Biotechnology, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
  • Challis C — Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Schretter CE — Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Rocha S — Biology and Biological Engineering Department, Chalmers University of Technology, Gothenburg 41296, Sweden.
  • Gradinaru V — Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Chesselet MF — Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  • Keshavarzian A — Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL 60612, USA.
  • Shannon KM — Department of Neurological Sciences, Section of Movement Disorders, Rush University Medical Center, Chicago, IL 60612, USA.
  • Krajmalnik-Brown R — Swette Center for Environmental Biotechnology, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
  • Wittung-Stafshede P — Biology and Biological Engineering Department, Chalmers University of Technology, Gothenburg 41296, Sweden.
  • Knight R — Department of Pediatrics, University of California, San Diego, San Diego, CA 92110, USA; Department of Computer Science and Engineering, University of California, San Diego, San Diego, CA 92093, USA.
  • Mazmanian SK — Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: sarkis@caltech.edu.
44 read4 want to readRigor 2.7Novelty 3.0Impact 3.4Reprod. 3.2

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0

Ken Park

Rigor 2/5Novelty 5/5Impact 2/5Reprod. 1/5

Interesting idea, small sample.

0

Tom Cohen

Rigor 1/5Novelty 4/5Impact 4/5Reprod. 4/5

Great figures and clear story.

0

Alex Cohen

Rigor 2/5Novelty 1/5Impact 2/5Reprod. 2/5

Important contribution to the field.

0

Ken Garcia

Rigor 5/5Novelty 2/5Impact 5/5Reprod. 1/5

Great figures and clear story.

0

Yuki Garcia

Rigor 4/5Novelty 5/5Impact 4/5Reprod. 3/5

Important contribution to the field.

0

Yuki Smith

Rigor 1/5Novelty 1/5Impact 2/5Reprod. 5/5

Solid methods, convincing results.

0

Ravi Rossi

Rigor 3/5Novelty 2/5Impact 5/5Reprod. 5/5

Important contribution to the field.

0

Omar Lee

Rigor 2/5Novelty 4/5Impact 5/5Reprod. 2/5

Replication is unclear to me.

0

Omar Park

Rigor 3/5Novelty 3/5Impact 4/5Reprod. 2/5

Nice but incremental.