Cell · 2016

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, Challis C, Schretter CE, Rocha S, Gradinaru V, Chesselet MF, Keshavarzian A, Shannon KM, Krajmalnik-Brown R, Wittung-Stafshede P, Knight R, Mazmanian SK.

Show affiliations
  • Sampson TRDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: trsamps@caltech.edu.
  • Debelius JWDepartment of Pediatrics, University of California, San Diego, San Diego, CA 92110, USA.
  • Thron TDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Janssen SDepartment of Pediatrics, University of California, San Diego, San Diego, CA 92110, USA.
  • Shastri GGDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Ilhan ZESwette Center for Environmental Biotechnology, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
  • Challis CDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Schretter CEDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Rocha SBiology and Biological Engineering Department, Chalmers University of Technology, Gothenburg 41296, Sweden.
  • Gradinaru VDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Chesselet MFDepartment of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
  • Keshavarzian ADepartment of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL 60612, USA.
  • Shannon KMDepartment of Neurological Sciences, Section of Movement Disorders, Rush University Medical Center, Chicago, IL 60612, USA.
  • Krajmalnik-Brown RSwette Center for Environmental Biotechnology, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
  • Wittung-Stafshede PBiology and Biological Engineering Department, Chalmers University of Technology, Gothenburg 41296, Sweden.
  • Knight RDepartment of Pediatrics, University of California, San Diego, San Diego, CA 92110, USA; Department of Computer Science and Engineering, University of California, San Diego, San Diego, CA 92093, USA.
  • Mazmanian SKDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: sarkis@caltech.edu.
44 read4 want to readRigor 2.7Novelty 3.0Impact 3.4Reprod. 3.2

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0

Ken Park

Rigor 2/5Novelty 5/5Impact 2/5Reprod. 1/5

Interesting idea, small sample.

0

Tom Cohen

Rigor 1/5Novelty 4/5Impact 4/5Reprod. 4/5

Great figures and clear story.

0

Alex Cohen

Rigor 2/5Novelty 1/5Impact 2/5Reprod. 2/5

Important contribution to the field.

0

Ken Garcia

Rigor 5/5Novelty 2/5Impact 5/5Reprod. 1/5

Great figures and clear story.

0

Yuki Garcia

Rigor 4/5Novelty 5/5Impact 4/5Reprod. 3/5

Important contribution to the field.

0

Yuki Smith

Rigor 1/5Novelty 1/5Impact 2/5Reprod. 5/5

Solid methods, convincing results.

0

Ravi Rossi

Rigor 3/5Novelty 2/5Impact 5/5Reprod. 5/5

Important contribution to the field.

0

Omar Lee

Rigor 2/5Novelty 4/5Impact 5/5Reprod. 2/5

Replication is unclear to me.

0

Omar Park

Rigor 3/5Novelty 3/5Impact 4/5Reprod. 2/5

Nice but incremental.