Cell · 2017

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

Subramanian A, Narayan R, Corsello SM, Peck DD, Natoli TE, Lu X, Gould J, Davis JF, Tubelli AA, Asiedu JK, Lahr DL, Hirschman JE, Liu Z, Donahue M, Julian B, Khan M, Wadden D, Smith IC, Lam D, Liberzon A, Toder C, Bagul M, Orzechowski M, Enache OM, Piccioni F, Johnson SA, Lyons NJ, Berger AH, Shamji AF, Brooks AN, Vrcic A, Flynn C, Rosains J, Takeda DY, Hu R, Davison D, Lamb J, Ardlie K, Hogstrom L, Greenside P, Gray NS, Clemons PA, Silver S, Wu X, Zhao WN, Read-Button W, Wu X, Haggarty SJ, Ronco LV, Boehm JS, Schreiber SL, Doench JG, Bittker JA, Root DE, Wong B, Golub TR.

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Subramanian A — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Narayan R — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Corsello SM — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.
Peck DD — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Natoli TE — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Lu X — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Gould J — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Davis JF — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Tubelli AA — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Asiedu JK — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Lahr DL — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Hirschman JE — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Liu Z — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Donahue M — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Julian B — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Khan M — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Wadden D — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Smith IC — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Lam D — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Liberzon A — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Toder C — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Bagul M — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Orzechowski M — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Enache OM — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Piccioni F — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Johnson SA — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Lyons NJ — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Berger AH — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.
Shamji AF — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Brooks AN — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.
Vrcic A — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Flynn C — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Rosains J — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Takeda DY — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.
Hu R — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Davison D — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Lamb J — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Ardlie K — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Hogstrom L — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Greenside P — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Gray NS — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Clemons PA — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Silver S — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Wu X — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Zhao WN — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Read-Button W — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Wu X — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Haggarty SJ — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Ronco LV — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Boehm JS — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Schreiber SL — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Doench JG — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Bittker JA — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Root DE — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Wong B — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Golub TR — Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: golub@broadinstitute.org.