Immunity · 2018

The Immune Landscape of Cancer

Thorsson V, Gibbs DL, Brown SD, Wolf D, Bortone DS, Ou Yang TH, Porta-Pardo E, Gao GF, Plaisier CL, Eddy JA, Ziv E, Culhane AC, Paull EO, Sivakumar IKA, Gentles AJ, Malhotra R, Farshidfar F, Colaprico A, Parker JS, Mose LE, Vo NS, Liu J, Liu Y, Rader J, Dhankani V, Reynolds SM, Bowlby R, Califano A, Cherniack AD, Anastassiou D, Bedognetti D, Mokrab Y, Newman AM, Rao A, Chen K, Krasnitz A, Hu H, Malta TM, Noushmehr H, Pedamallu CS, Bullman S, Ojesina AI, Lamb A, Zhou W, Shen H, Choueiri TK, Weinstein JN, Guinney J, Saltz J, Holt RA, Rabkin CS, Cancer Genome Atlas Research Network, Lazar AJ, Serody JS, Demicco EG, Disis ML, Vincent BG, Shmulevich I.

Show affiliations
  • Thorsson VInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA. Electronic address: vesteinn.thorsson@systemsbiology.org.
  • Gibbs DLInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA.
  • Brown SDCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
  • Wolf DUniversity of California, San Francisco, Box 0808, 2340 Sutter Street, S433, San Francisco, CA 94115, USA.
  • Bortone DSLineberger Comprehensive Cancer Center, Curriculum in Bioinformatics and Computational Biology, University of North Carolina, 125 Mason Farm Road, Chapel Hill, NC 27599-7295, USA.
  • Ou Yang THDepartment of Systems Biology and Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.
  • Porta-Pardo EBarcelona Supercomputing Centre, c/Jordi Girona, 29, 08034 Barcelona, Spain; SBP Medical Discovery Institute, La Jolla, CA 92037, USA.
  • Gao GFThe Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
  • Plaisier CLInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA; School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85281, USA.
  • Eddy JASage Bionetworks, 2901 Third Ave, Suite 330, Seattle, WA 98121, USA.
  • Ziv EDepartment of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1450 3rd St, San Francisco, CA 94143, USA.
  • Culhane ACDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Paull EOIrving Cancer Research Center, Room 913,1130 St. Nicholas Avenue, New York, NY 10032, USA.
  • Sivakumar IKADepartment of Computer Science, Institute for Computational Medicine; Johns Hopkins University, Baltimore, MD 21218, USA.
  • Gentles AJDepartments of Medicine and Biomedical Data Science, Stanford University, Stanford, CA 94305, USA.
  • Malhotra RSeven Bridges Genomics, Cambridge, MA 02142, USA.
  • Farshidfar FDepartment of Oncology, University of Calgary, Calgary, AB T2N 4N1, Canada.
  • Colaprico AUniversite libre de Bruxelles (ULB), Computer Science Department, Faculty of Sciences, Boulevard du Triomphe - CP212, 1050 Bruxelles, Belgium.
  • Parker JSLineberger Comprehensive Cancer Center, Curriculum in Bioinformatics and Computational Biology, University of North Carolina, 125 Mason Farm Road, Chapel Hill, NC 27599-7295, USA.
  • Mose LELineberger Comprehensive Cancer Center, Curriculum in Bioinformatics and Computational Biology, University of North Carolina, 125 Mason Farm Road, Chapel Hill, NC 27599-7295, USA.
  • Vo NSDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Liu JChan Soon-Shiong Institute of Molecular Medicine at Windber, Windber, PA 15963, USA.
  • Liu YDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Rader JMedical College of Wisconsin, 9200 Wisconsin Avenue, Milwaukee, WI 53226 USA.
  • Dhankani VInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA.
  • Reynolds SMInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA.
  • Bowlby RCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
  • Califano AIrving Cancer Research Center, Room 913,1130 St. Nicholas Avenue, New York, NY 10032, USA.
  • Cherniack ADThe Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
  • Anastassiou DDepartment of Systems Biology and Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.
  • Bedognetti DDivision of Translational Medicine, Research Branch, Sidra Medical and Research Center, PO Box 26999, Doha, Qatar.
  • Mokrab YDivision of Translational Medicine, Research Branch, Sidra Medical and Research Center, PO Box 26999, Doha, Qatar.
  • Newman AMInstitute for Stem Cell Biology and Regenerative Medicine and Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA.
  • Rao ADepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Chen KDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Krasnitz ASimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
  • Hu HChan Soon-Shiong Institute of Molecular Medicine at Windber, Windber, PA 15963, USA.
  • Malta TMDepartment of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA; Department of Genetics, Ribeirao Preto Medical School, University of São Paulo, São Paulo, Brazil.
  • Noushmehr HDepartment of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA; Department of Genetics, Ribeirao Preto Medical School, University of São Paulo, São Paulo, Brazil.
  • Pedamallu CSDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Bullman SDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Ojesina AIUniversity of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Lamb ASage Bionetworks, 2901 Third Ave, Suite 330, Seattle, WA 98121, USA.
  • Zhou WCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
  • Shen HCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
  • Choueiri TKDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Weinstein JNDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Guinney JSage Bionetworks, 2901 Third Ave, Suite 330, Seattle, WA 98121, USA.
  • Saltz JDepartment of Biomedical Informatics, Stony Brook Medicine, 100 Nicolls Rd, Stony Brook, NY 11794, USA.
  • Holt RACanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
  • Rabkin CSDivision of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr., Bethesda, MD 20892, USA.
  • Lazar AJDepartments of Pathology, Genomics Medicine and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd-Unit 85, Houston, TX 77030, USA.
  • Serody JSDepartment of Medicine and Microbiology and Lineberger Comprehensive Cancer Center, 125 Mason Farm Road, Chapel Hill, NC 27599-7295, USA.
  • Demicco EGMount Sinai Hospital, Department of Pathology and Laboratory Medicine, 600 University Ave., Toronto, ON M5G 1X5, Canada.
  • Disis MLUW Medicine Cancer Vaccine Institute, 850 Republican Street, Brotman Building, 2nd Floor, Room 221, Box 358050, University of Washington, Seattle, WA 98109-4714, USA.
  • Vincent BGLineberger Comprehensive Cancer Center, Curriculum in Bioinformatics and Computational Biology, University of North Carolina, 125 Mason Farm Road, Chapel Hill, NC 27599-7295, USA. Electronic address: benjamin.vincent@unchealth.unc.edu.
  • Shmulevich IInstitute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA. Electronic address: ilya.shmulevich@systemsbiology.org.
68 read9 want to readRigor 2.9Novelty 2.8Impact 3.2Reprod. 3.0

Most-cited papers citing this

  • Genome Biol · 2026 · cited by 8
  • Cancer Cell · 2026 · cited by 4
  • Cell Rep Med · 2026 · cited by 1
  • Apoptosis · 2026 · cited by 1
  • Immun Inflamm Dis · 2026 · cited by 1

Log in to like, log, and share thoughts on this paper.

Discussion

Share your thoughts above to start a thread. Constructive feedback only — reply to and like others’ posts.

0

Tariq Brown

Rigor 4/5Novelty 4/5Impact 4/5Reprod. 4/5

Interesting idea, small sample.

0

Maya Brown

Rigor 1/5Novelty 1/5Impact 1/5Reprod. 1/5

Solid methods, convincing results.

0

Omar Silva

Rigor 2/5Novelty 3/5Impact 5/5Reprod. 3/5

Solid methods, convincing results.

0

Maya Cohen

Rigor 4/5Novelty 4/5Impact 4/5Reprod. 3/5

Nice but incremental.

0

Tariq Rossi

Rigor 2/5Novelty 2/5Impact 4/5Reprod. 1/5

Great figures and clear story.

0

Mei Rossi

Rigor 1/5Novelty 1/5Impact 1/5Reprod. 5/5

Solid methods, convincing results.

0

Noor Kim

Rigor 2/5Novelty 2/5Impact 4/5Reprod. 1/5

Important contribution to the field.

0

Sam Wang

Rigor 1/5Novelty 3/5Impact 2/5Reprod. 3/5

Interesting idea, small sample.

0

Tom Garcia

Rigor 4/5Novelty 4/5Impact 4/5Reprod. 2/5

Great figures and clear story.

0

Mei Kim

Rigor 4/5Novelty 5/5Impact 5/5Reprod. 2/5

Important contribution to the field.

0

Ines Mueller

Rigor 2/5Novelty 3/5Impact 3/5Reprod. 4/5

Nice but incremental.

0

Ravi Brown

Rigor 2/5Novelty 1/5Impact 3/5Reprod. 4/5

Nice but incremental.

0

Tariq Khan

Rigor 3/5Novelty 2/5Impact 1/5Reprod. 4/5

Nice but incremental.

0

Eva Silva

Rigor 2/5Novelty 2/5Impact 2/5Reprod. 4/5

Great figures and clear story.

0

Liam Cohen

Rigor 2/5Novelty 2/5Impact 1/5Reprod. 1/5

Great figures and clear story.

0

Tariq Park

Rigor 2/5Novelty 5/5Impact 3/5Reprod. 3/5

Important contribution to the field.

0

Eva Park

Rigor 1/5Novelty 5/5Impact 2/5Reprod. 4/5

Great figures and clear story.

0

Ken Cohen

Rigor 4/5Novelty 1/5Impact 4/5Reprod. 4/5

Nice but incremental.

0

Pablo Wang

Rigor 5/5Novelty 1/5Impact 3/5Reprod. 4/5

Important contribution to the field.

0

Hugo Wang

Rigor 3/5Novelty 5/5Impact 1/5Reprod. 4/5

Interesting idea, small sample.

0

Eva Patel

Rigor 4/5Novelty 4/5Impact 5/5Reprod. 1/5

Interesting idea, small sample.

0

Liam Smith

Rigor 4/5Novelty 1/5Impact 2/5Reprod. 3/5

Nice but incremental.

0

Ines Lee

Rigor 5/5Novelty 4/5Impact 3/5Reprod. 5/5

Great figures and clear story.

0

Ravi Kim

Rigor 5/5Novelty 5/5Impact 3/5Reprod. 4/5

Important contribution to the field.