Nature · 2019

Next-generation characterization of the Cancer Cell Line Encyclopedia

Ghandi M, Huang FW, Jané-Valbuena J, Kryukov GV, Lo CC, McDonald ER, Barretina J, Gelfand ET, Bielski CM, Li H, Hu K, Andreev-Drakhlin AY, Kim J, Hess JM, Haas BJ, Aguet F, Weir BA, Rothberg MV, Paolella BR, Lawrence MS, Akbani R, Lu Y, Tiv HL, Gokhale PC, de Weck A, Mansour AA, Oh C, Shih J, Hadi K, Rosen Y, Bistline J, Venkatesan K, Reddy A, Sonkin D, Liu M, Lehar J, Korn JM, Porter DA, Jones MD, Golji J, Caponigro G, Taylor JE, Dunning CM, Creech AL, Warren AC, McFarland JM, Zamanighomi M, Kauffmann A, Stransky N, Imielinski M, Maruvka YE, Cherniack AD, Tsherniak A, Vazquez F, Jaffe JD, Lane AA, Weinstock DM, Johannessen CM, Morrissey MP, Stegmeier F, Schlegel R, Hahn WC, Getz G, Mills GB, Boehm JS, Golub TR, Garraway LA, Sellers WR.

Show affiliations
  • Ghandi M — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Huang FW — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Jané-Valbuena J — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Kryukov GV — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Lo CC — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • McDonald ER 3rd — Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Barretina J — Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Gelfand ET — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Bielski CM — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Li H — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Hu K — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Andreev-Drakhlin AY — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Kim J — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Hess JM — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Haas BJ — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Aguet F — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Weir BA — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Rothberg MV — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Paolella BR — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Lawrence MS — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Akbani R — The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Lu Y — The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Tiv HL — Belfer Center for Applied Cancer Science, Boston, MA, USA.
  • Gokhale PC — Belfer Center for Applied Cancer Science, Boston, MA, USA.
  • de Weck A — Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Mansour AA — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Oh C — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Shih J — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Hadi K — New York Genome Center, New York, NY, USA.
  • Rosen Y — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Bistline J — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Venkatesan K — Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Reddy A — Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Sonkin D — Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Liu M — Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Lehar J — Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Korn JM — Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Porter DA — Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Jones MD — Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Golji J — Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Caponigro G — Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Taylor JE — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Dunning CM — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Creech AL — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Warren AC — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • McFarland JM — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Zamanighomi M — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Kauffmann A — Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Stransky N — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Imielinski M — New York Genome Center, New York, NY, USA.
  • Maruvka YE — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Cherniack AD — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Tsherniak A — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Vazquez F — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Jaffe JD — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Lane AA — Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Weinstock DM — Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Johannessen CM — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Morrissey MP — Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Stegmeier F — Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Schlegel R — Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Hahn WC — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Getz G — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Mills GB — The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Boehm JS — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Golub TR — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Garraway LA — Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Sellers WR — Novartis Institutes for Biomedical Research, Cambridge, MA, USA. wsellers@broadinstitute.org.
Open on PubMed ↗Open at publisher ↗PMID 31068700
9 read2 want to readRigor 3.4Novelty 3.4Impact 3.1Reprod. 3.2

Most-cited papers citing this

  • Cancer Cell · 2026 · cited by 3
  • Nat Methods · 2026 · cited by 3
  • Nat Metab · 2026 · cited by 2
  • Nucleic Acids Res · 2026 · cited by 2
  • Nat Commun · 2025 · cited by 2

Log in to like, log, and share thoughts on this paper.

Discussion

Share your thoughts above to start a thread. Constructive feedback only — reply to and like others’ posts.

0

Tom Garcia

Rigor 1/5Novelty 5/5Impact 3/5Reprod. 3/5

Important contribution to the field.

0

Sam Nguyen

Rigor 3/5Novelty 3/5Impact 2/5Reprod. 5/5

Nice but incremental.

0

Tom Wang

Rigor 4/5Novelty 4/5Impact 4/5Reprod. 5/5

Important contribution to the field.