Nature · 2016

The antibody aducanumab reduces Aβ plaques in Alzheimer's disease

Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A.

Show affiliations
  • Sevigny J — Biogen, Cambridge, Massachusetts 02142, USA.
  • Chiao P — Biogen, Cambridge, Massachusetts 02142, USA.
  • Bussière T — Biogen, Cambridge, Massachusetts 02142, USA.
  • Weinreb PH — Biogen, Cambridge, Massachusetts 02142, USA.
  • Williams L — Biogen, Cambridge, Massachusetts 02142, USA.
  • Maier M — Neurimmune, Schlieren-Zurich 8952, Switzerland.
  • Dunstan R — Biogen, Cambridge, Massachusetts 02142, USA.
  • Salloway S — Butler Hospital, Providence, Rhode Island 02906, USA.
  • Chen T — Biogen, Cambridge, Massachusetts 02142, USA.
  • Ling Y — Biogen, Cambridge, Massachusetts 02142, USA.
  • O'Gorman J — Biogen, Cambridge, Massachusetts 02142, USA.
  • Qian F — Biogen, Cambridge, Massachusetts 02142, USA.
  • Arastu M — Biogen, Cambridge, Massachusetts 02142, USA.
  • Li M — Biogen, Cambridge, Massachusetts 02142, USA.
  • Chollate S — Biogen, Cambridge, Massachusetts 02142, USA.
  • Brennan MS — Biogen, Cambridge, Massachusetts 02142, USA.
  • Quintero-Monzon O — Biogen, Cambridge, Massachusetts 02142, USA.
  • Scannevin RH — Biogen, Cambridge, Massachusetts 02142, USA.
  • Arnold HM — Biogen, Cambridge, Massachusetts 02142, USA.
  • Engber T — Biogen, Cambridge, Massachusetts 02142, USA.
  • Rhodes K — Biogen, Cambridge, Massachusetts 02142, USA.
  • Ferrero J — Biogen, Cambridge, Massachusetts 02142, USA.
  • Hang Y — Biogen, Cambridge, Massachusetts 02142, USA.
  • Mikulskis A — Biogen, Cambridge, Massachusetts 02142, USA.
  • Grimm J — Neurimmune, Schlieren-Zurich 8952, Switzerland.
  • Hock C — Neurimmune, Schlieren-Zurich 8952, Switzerland.
  • Nitsch RM — Neurimmune, Schlieren-Zurich 8952, Switzerland.
  • Sandrock A — Biogen, Cambridge, Massachusetts 02142, USA.
51 read8 want to readRigor 3.0Novelty 3.1Impact 3.1Reprod. 2.8

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Discussion

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0

Jonas Silva

Rigor 5/5Novelty 3/5Impact 5/5Reprod. 4/5

Replication is unclear to me.

0

Lena Silva

Rigor 4/5Novelty 4/5Impact 5/5Reprod. 3/5

Important contribution to the field.

0

Maya Kim

Rigor 3/5Novelty 4/5Impact 3/5Reprod. 1/5

Interesting idea, small sample.

0

Mei Kim

Rigor 3/5Novelty 3/5Impact 5/5Reprod. 4/5

Important contribution to the field.

0

Hugo Kim

Rigor 1/5Novelty 5/5Impact 2/5Reprod. 1/5

Important contribution to the field.

0

Sara Kim

Rigor 1/5Novelty 5/5Impact 5/5Reprod. 5/5

Great figures and clear story.

0

Pablo Garcia

Rigor 2/5Novelty 5/5Impact 2/5Reprod. 3/5

Great figures and clear story.

0

Sam Patel

Rigor 1/5Novelty 2/5Impact 5/5Reprod. 4/5

Important contribution to the field.

0

Hugo Lee

Rigor 5/5Novelty 1/5Impact 1/5Reprod. 5/5

Replication is unclear to me.

0

Alex Nguyen

Rigor 3/5Novelty 5/5Impact 1/5Reprod. 1/5

Nice but incremental.

0

Lena Nguyen

Rigor 5/5Novelty 4/5Impact 5/5Reprod. 1/5

Replication is unclear to me.

0

Tom Cohen

Rigor 4/5Novelty 2/5Impact 1/5Reprod. 1/5

Interesting idea, small sample.

0

Jonas Cohen

Rigor 4/5Novelty 4/5Impact 3/5Reprod. 4/5

Replication is unclear to me.

0

Noor Rossi

Rigor 2/5Novelty 3/5Impact 3/5Reprod. 3/5

Nice but incremental.

0

Noor Kim

Rigor 2/5Novelty 1/5Impact 3/5Reprod. 5/5

Solid methods, convincing results.

0

Ines Wang

Rigor 4/5Novelty 3/5Impact 3/5Reprod. 1/5

Interesting idea, small sample.