Cell · 2017

Defining a Cancer Dependency Map

Tsherniak A, Vazquez F, Montgomery PG, Weir BA, Kryukov G, Cowley GS, Gill S, Harrington WF, Pantel S, Krill-Burger JM, Meyers RM, Ali L, Goodale A, Lee Y, Jiang G, Hsiao J, Gerath WFJ, Howell S, Merkel E, Ghandi M, Garraway LA, Root DE, Golub TR, Boehm JS, Hahn WC.

Show affiliations
  • Tsherniak ABroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Vazquez FBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA.
  • Montgomery PGBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Weir BABroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA.
  • Kryukov GBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA.
  • Cowley GSBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Gill SBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA.
  • Harrington WFBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Pantel SBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Krill-Burger JMBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Meyers RMBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Ali LBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Goodale ABroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Lee YBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Jiang GBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Hsiao JBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Gerath WFJBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Howell SBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Merkel EBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Ghandi MBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Garraway LABroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA, USA; Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD, USA.
  • Root DEBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Golub TRBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA, USA; Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD, USA.
  • Boehm JSBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Hahn WCBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA, USA. Electronic address: william_hahn@dfci.harvard.edu.
37 read7 want to readRigor 2.8Novelty 2.9Impact 3.1Reprod. 3.3

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Discussion

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0

Ines Sato

Rigor 1/5Novelty 1/5Impact 5/5Reprod. 5/5

Important contribution to the field.

1

Ken Patel

Rigor 2/5Novelty 2/5Impact 4/5Reprod. 5/5

Solid methods, convincing results.

0

Jonas Khan

Rigor 4/5Novelty 1/5Impact 2/5Reprod. 4/5

Nice but incremental.

0

Omar Silva

Rigor 1/5Novelty 2/5Impact 4/5Reprod. 3/5

Interesting idea, small sample.

0

Mei Nguyen

Rigor 1/5Novelty 1/5Impact 2/5Reprod. 1/5

Solid methods, convincing results.

0

Alex Nguyen

Rigor 5/5Novelty 3/5Impact 1/5Reprod. 5/5

Replication is unclear to me.

0

Hugo Park

Rigor 5/5Novelty 1/5Impact 1/5Reprod. 4/5

Great figures and clear story.

0

Lena Rossi

Rigor 1/5Novelty 4/5Impact 4/5Reprod. 1/5

Important contribution to the field.

0

Ken Kim

Rigor 3/5Novelty 1/5Impact 5/5Reprod. 3/5

Important contribution to the field.