Cell · 2017

Defining a Cancer Dependency Map

Tsherniak A, Vazquez F, Montgomery PG, Weir BA, Kryukov G, Cowley GS, Gill S, Harrington WF, Pantel S, Krill-Burger JM, Meyers RM, Ali L, Goodale A, Lee Y, Jiang G, Hsiao J, Gerath WFJ, Howell S, Merkel E, Ghandi M, Garraway LA, Root DE, Golub TR, Boehm JS, Hahn WC.

Show affiliations
  • Tsherniak A — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Vazquez F — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA.
  • Montgomery PG — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Weir BA — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA.
  • Kryukov G — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA.
  • Cowley GS — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Gill S — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA.
  • Harrington WF — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Pantel S — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Krill-Burger JM — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Meyers RM — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Ali L — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Goodale A — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Lee Y — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Jiang G — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Hsiao J — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Gerath WFJ — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Howell S — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Merkel E — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Ghandi M — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Garraway LA — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA, USA; Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD, USA.
  • Root DE — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Golub TR — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA, USA; Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD, USA.
  • Boehm JS — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA.
  • Hahn WC — Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA, USA. Electronic address: william_hahn@dfci.harvard.edu.
37 read7 want to readRigor 2.8Novelty 2.9Impact 3.1Reprod. 3.3

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Discussion

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0

Ines Sato

Rigor 1/5Novelty 1/5Impact 5/5Reprod. 5/5

Important contribution to the field.

1

Ken Patel

Rigor 2/5Novelty 2/5Impact 4/5Reprod. 5/5

Solid methods, convincing results.

0

Jonas Khan

Rigor 4/5Novelty 1/5Impact 2/5Reprod. 4/5

Nice but incremental.

0

Omar Silva

Rigor 1/5Novelty 2/5Impact 4/5Reprod. 3/5

Interesting idea, small sample.

0

Mei Nguyen

Rigor 1/5Novelty 1/5Impact 2/5Reprod. 1/5

Solid methods, convincing results.

0

Alex Nguyen

Rigor 5/5Novelty 3/5Impact 1/5Reprod. 5/5

Replication is unclear to me.

0

Hugo Park

Rigor 5/5Novelty 1/5Impact 1/5Reprod. 4/5

Great figures and clear story.

0

Lena Rossi

Rigor 1/5Novelty 4/5Impact 4/5Reprod. 1/5

Important contribution to the field.

0

Ken Kim

Rigor 3/5Novelty 1/5Impact 5/5Reprod. 3/5

Important contribution to the field.