Cell · 2014

A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping

Rao SS, Huntley MH, Durand NC, Stamenova EK, Bochkov ID, Robinson JT, Sanborn AL, Machol I, Omer AD, Lander ES, Aiden EL.

Show affiliations
  • Rao SSThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Computer Science, Department of Computational and Applied Mathematics, Rice University, Houston, TX 77005, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.
  • Huntley MHThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Computer Science, Department of Computational and Applied Mathematics, Rice University, Houston, TX 77005, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  • Durand NCThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Computer Science, Department of Computational and Applied Mathematics, Rice University, Houston, TX 77005, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.
  • Stamenova EKThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Computer Science, Department of Computational and Applied Mathematics, Rice University, Houston, TX 77005, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.
  • Bochkov IDThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Computer Science, Department of Computational and Applied Mathematics, Rice University, Houston, TX 77005, USA.
  • Robinson JTThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.
  • Sanborn ALThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Computer Science, Department of Computational and Applied Mathematics, Rice University, Houston, TX 77005, USA; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.
  • Machol IThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Computer Science, Department of Computational and Applied Mathematics, Rice University, Houston, TX 77005, USA.
  • Omer ADThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Computer Science, Department of Computational and Applied Mathematics, Rice University, Houston, TX 77005, USA.
  • Lander ESBroad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: lander@broadinstitute.org.
  • Aiden ELThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Computer Science, Department of Computational and Applied Mathematics, Rice University, Houston, TX 77005, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Center for Theoretical Biological Physics, Rice University, Houston, TX 77030, USA. Electronic address: erez@erez.com.
45 read7 want to readRigor 3.4Novelty 2.9Impact 3.2Reprod. 2.5

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0

Pablo Sato

Rigor 4/5Novelty 5/5Impact 4/5Reprod. 5/5

Great figures and clear story.

0

Sam Khan

Rigor 2/5Novelty 1/5Impact 3/5Reprod. 2/5

Great figures and clear story.

0

Mei Silva

Rigor 2/5Novelty 1/5Impact 5/5Reprod. 1/5

Solid methods, convincing results.

0

Noor Park

Rigor 2/5Novelty 2/5Impact 2/5Reprod. 1/5

Interesting idea, small sample.

0

Mei Park

Rigor 5/5Novelty 2/5Impact 5/5Reprod. 5/5

Important contribution to the field.

0

Mei Rossi

Rigor 5/5Novelty 4/5Impact 2/5Reprod. 1/5

Solid methods, convincing results.

0

Omar Mueller

Rigor 5/5Novelty 2/5Impact 4/5Reprod. 1/5

Great figures and clear story.

0

Sam Mueller

Rigor 2/5Novelty 2/5Impact 1/5Reprod. 4/5

Important contribution to the field.

0

Ines Wang

Rigor 4/5Novelty 3/5Impact 4/5Reprod. 1/5

Replication is unclear to me.

0

Noor Lee

Rigor 4/5Novelty 4/5Impact 1/5Reprod. 1/5

Important contribution to the field.

0

Omar Lee

Rigor 3/5Novelty 1/5Impact 3/5Reprod. 2/5

Great figures and clear story.

0

Omar Kim

Rigor 2/5Novelty 2/5Impact 2/5Reprod. 5/5

Nice but incremental.

0

Ken Lee

Rigor 1/5Novelty 3/5Impact 1/5Reprod. 2/5

Great figures and clear story.

0

Lena Garcia

Rigor 4/5Novelty 2/5Impact 2/5Reprod. 5/5

Solid methods, convincing results.

0

Ravi Patel

Rigor 2/5Novelty 3/5Impact 3/5Reprod. 3/5

Nice but incremental.