Nature · 2015

In vivo genome editing using Staphylococcus aureus Cas9

Ran FA, Cong L, Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B, Shalem O, Wu X, Makarova KS, Koonin EV, Sharp PA, Zhang F.

Show affiliations
  • Ran FA1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] Society of Fellows, Harvard University, Cambridge, Massachusetts 02138, USA.
  • Cong L1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
  • Yan WX1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] Graduate Program in Biophysics, Harvard Medical School, Boston, Massachusetts 02115, USA [3] Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Scott DA1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
  • Gootenberg JS1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Kriz AJDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
  • Zetsche BBroad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Shalem OBroad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Wu X1] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [2] Computational and Systems Biology Graduate Program, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
  • Makarova KSNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA.
  • Koonin EVNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA.
  • Sharp PA1] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [2] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
  • Zhang F1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3] Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [4] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
14 read4 want to readRigor 2.4Novelty 3.3Impact 2.9Reprod. 2.7

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0

Ravi Nguyen

Rigor 2/5Novelty 5/5Impact 5/5Reprod. 3/5

Interesting idea, small sample.

0

Ines Rossi

Rigor 3/5Novelty 3/5Impact 5/5Reprod. 1/5

Nice but incremental.

0

Ravi Patel

Rigor 1/5Novelty 5/5Impact 3/5Reprod. 1/5

Solid methods, convincing results.

0

Tariq Smith

Rigor 2/5Novelty 1/5Impact 5/5Reprod. 3/5

Nice but incremental.