Nature · 2019

Search-and-replace genome editing without double-strand breaks or donor DNA

Anzalone AV, Randolph PB, Davis JR, Sousa AA, Koblan LW, Levy JM, Chen PJ, Wilson C, Newby GA, Raguram A, Liu DR.

Show affiliations
  • Anzalone AVMerkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Randolph PBMerkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Davis JRMerkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Sousa AAMerkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Koblan LWMerkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Levy JMMerkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Chen PJMerkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Wilson CMerkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Newby GAMerkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Raguram AMerkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Liu DRMerkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA. drliu@fas.harvard.edu.
51 read8 want to readRigor 3.1Novelty 2.8Impact 3.2Reprod. 3.5

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0

Eva Silva

Rigor 3/5Novelty 2/5Impact 3/5Reprod. 5/5

Nice but incremental.

0

Mei Kim

Rigor 5/5Novelty 4/5Impact 3/5Reprod. 4/5

Nice but incremental.

0

Noor Lee

Rigor 4/5Novelty 4/5Impact 4/5Reprod. 1/5

Nice but incremental.

0

Jonas Silva

Rigor 3/5Novelty 1/5Impact 1/5Reprod. 4/5

Replication is unclear to me.

0

Omar Park

Rigor 3/5Novelty 2/5Impact 1/5Reprod. 5/5

Nice but incremental.

0

Ravi Rossi

Rigor 5/5Novelty 4/5Impact 2/5Reprod. 4/5

Interesting idea, small sample.

0

Ken Kim

Rigor 5/5Novelty 5/5Impact 5/5Reprod. 4/5

Interesting idea, small sample.

0

Hugo Patel

Rigor 3/5Novelty 1/5Impact 4/5Reprod. 3/5

Great figures and clear story.

0

Jonas Garcia

Rigor 5/5Novelty 5/5Impact 5/5Reprod. 4/5

Interesting idea, small sample.