Science · 2016

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B.

Show affiliations
  • Hong S — F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Beja-Glasser VF — F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Nfonoyim BM — F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Frouin A — F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Li S — Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Ramakrishnan S — F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Merry KM — F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Shi Q — Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Rosenthal A — Alector Inc., 953 Indiana St, San Francisco, California 94107, USA.
  • Barres BA — Department of Neurobiology, Stanford University School of Medicine, Palo Alto, California 94305, USA.
  • Lemere CA — Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Selkoe DJ — Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Stevens B — F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
69 read13 want to readRigor 3.1Novelty 2.7Impact 3.0Reprod. 3.2

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0

Omar Mueller

Rigor 4/5Novelty 3/5Impact 3/5Reprod. 5/5

Replication is unclear to me.

0

Alex Sato

Rigor 1/5Novelty 5/5Impact 4/5Reprod. 1/5

Interesting idea, small sample.

0

Alex Nguyen

Rigor 5/5Novelty 1/5Impact 5/5Reprod. 1/5

Great figures and clear story.

0

Pablo Park

Rigor 5/5Novelty 3/5Impact 5/5Reprod. 2/5

Interesting idea, small sample.

0

Tom Nguyen

Rigor 4/5Novelty 5/5Impact 5/5Reprod. 3/5

Replication is unclear to me.

0

Pablo Kim

Rigor 3/5Novelty 4/5Impact 2/5Reprod. 3/5

Solid methods, convincing results.

0

Tariq Lee

Rigor 1/5Novelty 5/5Impact 3/5Reprod. 4/5

Nice but incremental.

0

Eva Patel

Rigor 1/5Novelty 2/5Impact 1/5Reprod. 1/5

Replication is unclear to me.

0

Liam Patel

Rigor 2/5Novelty 5/5Impact 3/5Reprod. 5/5

Important contribution to the field.

0

Lena Patel

Rigor 2/5Novelty 1/5Impact 4/5Reprod. 5/5

Great figures and clear story.

0

Ines Lee

Rigor 1/5Novelty 2/5Impact 2/5Reprod. 3/5

Nice but incremental.

0

Ken Smith

Rigor 4/5Novelty 5/5Impact 2/5Reprod. 5/5

Great figures and clear story.

0

Alex Khan

Rigor 4/5Novelty 2/5Impact 1/5Reprod. 1/5

Important contribution to the field.

0

Jonas Silva

Rigor 4/5Novelty 3/5Impact 3/5Reprod. 2/5

Nice but incremental.

0

Maya Cohen

Rigor 4/5Novelty 3/5Impact 1/5Reprod. 3/5

Solid methods, convincing results.

0

Mei Nguyen

Rigor 1/5Novelty 2/5Impact 4/5Reprod. 4/5

Interesting idea, small sample.

0

Sara Cohen

Rigor 5/5Novelty 4/5Impact 3/5Reprod. 1/5

Important contribution to the field.

0

Noor Rossi

Rigor 4/5Novelty 1/5Impact 3/5Reprod. 4/5

Interesting idea, small sample.

0

Alex Kim

Rigor 1/5Novelty 1/5Impact 1/5Reprod. 1/5

Replication is unclear to me.

0

Yuki Wang

Rigor 2/5Novelty 1/5Impact 5/5Reprod. 5/5

Important contribution to the field.

0

Sara Patel

Rigor 3/5Novelty 3/5Impact 2/5Reprod. 5/5

Solid methods, convincing results.

0

Tom Lee

Rigor 2/5Novelty 5/5Impact 5/5Reprod. 3/5

Great figures and clear story.