Science · 2017

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, Wong F, Azad NS, Rucki AA, Laheru D, Donehower R, Zaheer A, Fisher GA, Crocenzi TS, Lee JJ, Greten TF, Duffy AG, Ciombor KK, Eyring AD, Lam BH, Joe A, Kang SP, Holdhoff M, Danilova L, Cope L, Meyer C, Zhou S, Goldberg RM, Armstrong DK, Bever KM, Fader AN, Taube J, Housseau F, Spetzler D, Xiao N, Pardoll DM, Papadopoulos N, Kinzler KW, Eshleman JR, Vogelstein B, Anders RA, Diaz LA.

Show affiliations
  • Le DT — Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Durham JN — Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Smith KN — Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Wang H — Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Bartlett BR — Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA.
  • Aulakh LK — Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA.
  • Lu S — Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA.
  • Kemberling H — Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Wilt C — Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Luber BS — Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Wong F — Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA.
  • Azad NS — Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Rucki AA — Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Laheru D — Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Donehower R — Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Zaheer A — Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Fisher GA — Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Crocenzi TS — Providence Cancer Center at Providence Health & Services, Portland, OR 97213, USA.
  • Lee JJ — Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA.
  • Greten TF — Gastrointestinal Malignancies Section, Thoracic-GI Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Duffy AG — Gastrointestinal Malignancies Section, Thoracic-GI Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Ciombor KK — Division of Medical Oncology, Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
  • Eyring AD — Merck & Co. Inc., Kenilworth, NJ 07033, USA.
  • Lam BH — Merck & Co. Inc., Kenilworth, NJ 07033, USA.
  • Joe A — Merck & Co. Inc., Kenilworth, NJ 07033, USA.
  • Kang SP — Merck & Co. Inc., Kenilworth, NJ 07033, USA.
  • Holdhoff M — Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Danilova L — Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Cope L — Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Meyer C — Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Zhou S — Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Goldberg RM — West Virginia University Cancer Institute, Morgantown, WV 26506, USA.
  • Armstrong DK — Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Bever KM — Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Fader AN — Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD 21287, USA.
  • Taube J — Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Housseau F — Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Spetzler D — Caris Life Sciences, Phoenix, AZ 85040, USA.
  • Xiao N — Caris Life Sciences, Phoenix, AZ 85040, USA.
  • Pardoll DM — Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Papadopoulos N — Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Kinzler KW — Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Eshleman JR — Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Vogelstein B — Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Anders RA — Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Diaz LA Jr — Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA. ldiaz@mskcc.org.
Open on PubMed ↗Open at publisher ↗PMID 28596308
17 read3 want to readRigor 3.3Novelty 2.5Impact 2.9Reprod. 3.5

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Noor Brown

Rigor 4/5Novelty 1/5Impact 5/5Reprod. 2/5

Important contribution to the field.

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Sam Kim

Rigor 4/5Novelty 2/5Impact 1/5Reprod. 3/5

Nice but incremental.