Physiol Rev · 2018

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

Yamamoto M, Kensler TW, Motohashi H.

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  • Yamamoto MDepartment of Medical Biochemistry, Graduate School of Medicine, Tohoku University , Sendai , Japan ; Department of Pharmacology & Chemical Biology, University of Pittsburgh , Pittsburgh, Pennsylvania ; and Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University , Sendai , Japan.
  • Kensler TWDepartment of Medical Biochemistry, Graduate School of Medicine, Tohoku University , Sendai , Japan ; Department of Pharmacology & Chemical Biology, University of Pittsburgh , Pittsburgh, Pennsylvania ; and Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University , Sendai , Japan.
  • Motohashi HDepartment of Medical Biochemistry, Graduate School of Medicine, Tohoku University , Sendai , Japan ; Department of Pharmacology & Chemical Biology, University of Pittsburgh , Pittsburgh, Pennsylvania ; and Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University , Sendai , Japan.
36 read4 want to readRigor 3.0Novelty 2.5Impact 2.9Reprod. 3.3

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Hugo Brown

Rigor 4/5Novelty 5/5Impact 5/5Reprod. 2/5

Important contribution to the field.

0

Omar Brown

Rigor 3/5Novelty 2/5Impact 1/5Reprod. 2/5

Great figures and clear story.

0

Omar Smith

Rigor 2/5Novelty 5/5Impact 2/5Reprod. 5/5

Nice but incremental.

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Lena Garcia

Rigor 4/5Novelty 4/5Impact 4/5Reprod. 5/5

Replication is unclear to me.

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Maya Brown

Rigor 5/5Novelty 5/5Impact 2/5Reprod. 4/5

Interesting idea, small sample.

0

Pablo Brown

Rigor 2/5Novelty 2/5Impact 1/5Reprod. 5/5

Great figures and clear story.

0

Hugo Nguyen

Rigor 2/5Novelty 1/5Impact 2/5Reprod. 5/5

Solid methods, convincing results.

0

Noor Park

Rigor 4/5Novelty 4/5Impact 2/5Reprod. 5/5

Solid methods, convincing results.

0

Liam Park

Rigor 5/5Novelty 1/5Impact 1/5Reprod. 2/5

Replication is unclear to me.

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Sara Patel

Rigor 3/5Novelty 4/5Impact 3/5Reprod. 1/5

Important contribution to the field.