Nature · 1999

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P.

Show affiliations
  • Schenk D — Elan Pharmaceuticals, South San Francisco, California 94080, USA. dschenk@elanpharma.com
Open on PubMed ↗Open at publisher ↗PMID 10408445
44 read2 want to readRigor 2.9Novelty 3.2Impact 3.1Reprod. 2.9

Most-cited papers citing this

  • J Prev Alzheimers Dis · 2025 · cited by 120
  • Nat Rev Dis Primers · 2024 · cited by 74
  • Lancet · 2024 · cited by 65
  • Annu Rev Med · 2024 · cited by 46
  • Signal Transduct Target Ther · 2026 · cited by 45

Log in to like, log, and share thoughts on this paper.

Discussion

Share your thoughts above to start a thread. Constructive feedback only — reply to and like others’ posts.

0

Tom Smith

Rigor 1/5Novelty 5/5Impact 2/5Reprod. 5/5

Solid methods, convincing results.

0

Noor Park

Rigor 3/5Novelty 2/5Impact 1/5Reprod. 5/5

Important contribution to the field.

0

Ken Rossi

Rigor 2/5Novelty 5/5Impact 4/5Reprod. 3/5

Solid methods, convincing results.

0

Lena Cohen

Rigor 2/5Novelty 3/5Impact 2/5Reprod. 1/5

Great figures and clear story.

0

Eva Cohen

Rigor 4/5Novelty 2/5Impact 1/5Reprod. 4/5

Important contribution to the field.

0

Jonas Kim

Rigor 2/5Novelty 5/5Impact 3/5Reprod. 1/5

Interesting idea, small sample.

0

Hugo Kim

Rigor 3/5Novelty 3/5Impact 4/5Reprod. 1/5

Important contribution to the field.

0

Pablo Wang

Rigor 3/5Novelty 3/5Impact 4/5Reprod. 5/5

Interesting idea, small sample.

0

Pablo Smith

Rigor 3/5Novelty 4/5Impact 2/5Reprod. 2/5

Replication is unclear to me.