Nat Rev Mol Cell Biol · 2023

Long non-coding RNAs: definitions, functions, challenges and recommendations

Mattick JS, Amaral PP, Carninci P, Carpenter S, Chang HY, Chen LL, Chen R, Dean C, Dinger ME, Fitzgerald KA, Gingeras TR, Guttman M, Hirose T, Huarte M, Johnson R, Kanduri C, Kapranov P, Lawrence JB, Lee JT, Mendell JT, Mercer TR, Moore KJ, Nakagawa S, Rinn JL, Spector DL, Ulitsky I, Wan Y, Wilusz JE, Wu M.

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Mattick JS — School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, NSW, Australia. j.mattick@unsw.edu.au.
Amaral PP — INSPER Institute of Education and Research, São Paulo, Brazil.
Carninci P — RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Carpenter S — Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, USA.
Chang HY — Center for Personal Dynamics Regulomes, Stanford University School of Medicine, Stanford, CA, USA.
Chen LL — CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
Chen R — Key Laboratory of RNA Biology, Center for Big Data Research in Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Dean C — John Innes Centre, Norwich Research Park, Norwich, UK.
Dinger ME — School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, NSW, Australia.
Fitzgerald KA — Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Gingeras TR — Cold Spring Harbour Laboratory, Cold Spring Harbour, NY, USA.
Guttman M — Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Hirose T — Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.
Huarte M — Department of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.
Johnson R — School of Biology and Environmental Science, University College Dublin, Dublin, Ireland.
Kanduri C — Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Kapranov P — Institute of Genomics, School of Medicine, Huaqiao University, Xiamen, China.
Lawrence JB — Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Lee JT — Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mendell JT — Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, USA.
Mercer TR — Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD, Australia.
Moore KJ — Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Nakagawa S — RNA Biology Laboratory, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Rinn JL — Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Spector DL — Cold Spring Harbour Laboratory, Cold Spring Harbour, NY, USA.
Ulitsky I — Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Wan Y — Laboratory of RNA Genomics and Structure, Genome Institute of Singapore, A*STAR, Singapore, Singapore.
Wilusz JE — Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Therapeutic Innovation Center, Baylor College of Medicine, Houston, TX, USA.
Wu M — Translational Research Institute, Henan Provincial People's Hospital, Academy of Medical Science, Zhengzhou University, Zhengzhou, China.