Nat Biotechnol · 2015

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

Hilton IB, D'Ippolito AM, Vockley CM, Thakore PI, Crawford GE, Reddy TE, Gersbach CA.

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Hilton IB — 1] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. [2] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA.
D'Ippolito AM — 1] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA. [2] University Program in Genetics and Genomics, Duke University Medical Center, Durham, North Carolina, USA.
Vockley CM — 1] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA. [2] Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA.
Thakore PI — 1] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. [2] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA.
Crawford GE — 1] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA. [2] Department of Pediatrics, Division of Medical Genetics, Duke University Medical Center, Durham, North Carolina, USA.
Reddy TE — 1] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA. [2] Department of Biostatistics &Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA.
Gersbach CA — 1] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. [2] Center for Genomic &Computational Biology, Duke University, Durham, North Carolina, USA. [3] Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA.