Nat Rev Drug Discov · 2014

Drugging the undruggable RAS: Mission possible?

Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ.

Show affiliations
  • Cox ADLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
  • Fesik SWVanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
  • Kimmelman ACDana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
  • Luo JNational Cancer Institute, Bethesda, Maryland, 20892, USA.
  • Der CJLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
28 read7 want to readRigor 3.3Novelty 2.5Impact 3.2Reprod. 3.5

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Discussion

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0

Ravi Rossi

Rigor 4/5Novelty 1/5Impact 5/5Reprod. 4/5

Solid methods, convincing results.

0

Ken Wang

Rigor 4/5Novelty 3/5Impact 4/5Reprod. 5/5

Nice but incremental.

0

Mei Lee

Rigor 4/5Novelty 3/5Impact 2/5Reprod. 3/5

Replication is unclear to me.

0

Maya Brown

Rigor 3/5Novelty 3/5Impact 1/5Reprod. 5/5

Important contribution to the field.

0

Yuki Sato

Rigor 4/5Novelty 2/5Impact 4/5Reprod. 4/5

Interesting idea, small sample.

0

Omar Nguyen

Rigor 1/5Novelty 2/5Impact 4/5Reprod. 3/5

Important contribution to the field.

0

Ines Rossi

Rigor 2/5Novelty 3/5Impact 4/5Reprod. 3/5

Solid methods, convincing results.

0

Mei Mueller

Rigor 4/5Novelty 2/5Impact 4/5Reprod. 3/5

Interesting idea, small sample.

0

Tariq Rossi

Rigor 2/5Novelty 2/5Impact 5/5Reprod. 5/5

Interesting idea, small sample.

0

Tom Kim

Rigor 2/5Novelty 4/5Impact 1/5Reprod. 4/5

Nice but incremental.

0

Alex Wang

Rigor 2/5Novelty 2/5Impact 1/5Reprod. 4/5

Great figures and clear story.