Lancet · 2017

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C, Kim TY, Choo SP, Trojan J, Welling TH, Meyer T, Kang YK, Yeo W, Chopra A, Anderson J, Dela Cruz C, Lang L, Neely J, Tang H, Dastani HB, Melero I.

Show affiliations
  • El-Khoueiry AB — USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA. Electronic address: elkhouei@med.usc.edu.
  • Sangro B — Clinica Universidad de Navarra and CIBEREHD, Pamplona, Spain.
  • Yau T — University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Crocenzi TS — Providence Cancer Center, Portland, OR, USA.
  • Kudo M — Kindai University Faculty of Medicine, Osaka, Japan.
  • Hsu C — National Taiwan University Hospital, Taipei, Taiwan.
  • Kim TY — Seoul National University Hospital, Seoul, South Korea.
  • Choo SP — National Cancer Center, Singapore.
  • Trojan J — Goethe University Hospital and Cancer Center, Frankfurt, Germany.
  • Welling TH Rd — University of Michigan School of Medicine, Ann Arbor, MI, USA.
  • Meyer T — Royal Free Hospital, London, UK.
  • Kang YK — Asan Medical Center, University of Ulsan, Seoul, South Korea.
  • Yeo W — Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Chopra A — Johns Hopkins Singapore International Medical Centre, Singapore.
  • Anderson J — Bristol-Myers Squibb, Princeton, NJ, USA.
  • Dela Cruz C — Bristol-Myers Squibb, Princeton, NJ, USA.
  • Lang L — Bristol-Myers Squibb, Princeton, NJ, USA.
  • Neely J — Bristol-Myers Squibb, Princeton, NJ, USA.
  • Tang H — Bristol-Myers Squibb, Princeton, NJ, USA.
  • Dastani HB — Bristol-Myers Squibb, Princeton, NJ, USA.
  • Melero I — Biomedical Research Network in Oncology (CIBERONC), Pamplona, Spain; Center for Applied Medical Research (CIMA), Pamplona, Spain.
49 read12 want to readRigor 2.9Novelty 3.0Impact 3.2Reprod. 3.0

Most-cited papers citing this

  • Vaccines (Basel) · 2026 · cited by 5
  • Oncogene · 2026 · cited by 3
  • Aliment Pharmacol Ther · 2026 · cited by 3
  • Cancers (Basel) · 2026 · cited by 3
  • Int J Biol Sci · 2026 · cited by 3

Log in to like, log, and share thoughts on this paper.

Discussion

Share your thoughts above to start a thread. Constructive feedback only — reply to and like others’ posts.

0

Jonas Khan

Rigor 5/5Novelty 3/5Impact 5/5Reprod. 4/5

Solid methods, convincing results.

0

Tom Kim

Rigor 1/5Novelty 1/5Impact 3/5Reprod. 5/5

Nice but incremental.

0

Hugo Mueller

Rigor 4/5Novelty 3/5Impact 5/5Reprod. 1/5

Solid methods, convincing results.

0

Omar Mueller

Rigor 3/5Novelty 5/5Impact 2/5Reprod. 1/5

Great figures and clear story.

0

Pablo Garcia

Rigor 1/5Novelty 2/5Impact 4/5Reprod. 5/5

Great figures and clear story.

0

Pablo Sato

Rigor 4/5Novelty 2/5Impact 2/5Reprod. 5/5

Nice but incremental.

0

Omar Cohen

Rigor 1/5Novelty 1/5Impact 5/5Reprod. 1/5

Interesting idea, small sample.

0

Tariq Wang

Rigor 1/5Novelty 3/5Impact 2/5Reprod. 2/5

Important contribution to the field.

0

Tariq Smith

Rigor 1/5Novelty 5/5Impact 1/5Reprod. 5/5

Solid methods, convincing results.