Lancet · 2017

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C, Kim TY, Choo SP, Trojan J, Welling TH, Meyer T, Kang YK, Yeo W, Chopra A, Anderson J, Dela Cruz C, Lang L, Neely J, Tang H, Dastani HB, Melero I.

Show affiliations
  • El-Khoueiry ABUSC Norris Comprehensive Cancer Center, Los Angeles, CA, USA. Electronic address: elkhouei@med.usc.edu.
  • Sangro BClinica Universidad de Navarra and CIBEREHD, Pamplona, Spain.
  • Yau TUniversity of Hong Kong, Hong Kong Special Administrative Region, China.
  • Crocenzi TSProvidence Cancer Center, Portland, OR, USA.
  • Kudo MKindai University Faculty of Medicine, Osaka, Japan.
  • Hsu CNational Taiwan University Hospital, Taipei, Taiwan.
  • Kim TYSeoul National University Hospital, Seoul, South Korea.
  • Choo SPNational Cancer Center, Singapore.
  • Trojan JGoethe University Hospital and Cancer Center, Frankfurt, Germany.
  • Welling TH RdUniversity of Michigan School of Medicine, Ann Arbor, MI, USA.
  • Meyer TRoyal Free Hospital, London, UK.
  • Kang YKAsan Medical Center, University of Ulsan, Seoul, South Korea.
  • Yeo WChinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Chopra AJohns Hopkins Singapore International Medical Centre, Singapore.
  • Anderson JBristol-Myers Squibb, Princeton, NJ, USA.
  • Dela Cruz CBristol-Myers Squibb, Princeton, NJ, USA.
  • Lang LBristol-Myers Squibb, Princeton, NJ, USA.
  • Neely JBristol-Myers Squibb, Princeton, NJ, USA.
  • Tang HBristol-Myers Squibb, Princeton, NJ, USA.
  • Dastani HBBristol-Myers Squibb, Princeton, NJ, USA.
  • Melero IBiomedical Research Network in Oncology (CIBERONC), Pamplona, Spain; Center for Applied Medical Research (CIMA), Pamplona, Spain.
49 read12 want to readRigor 2.9Novelty 3.0Impact 3.2Reprod. 3.0

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0

Jonas Khan

Rigor 5/5Novelty 3/5Impact 5/5Reprod. 4/5

Solid methods, convincing results.

0

Tom Kim

Rigor 1/5Novelty 1/5Impact 3/5Reprod. 5/5

Nice but incremental.

0

Hugo Mueller

Rigor 4/5Novelty 3/5Impact 5/5Reprod. 1/5

Solid methods, convincing results.

0

Omar Mueller

Rigor 3/5Novelty 5/5Impact 2/5Reprod. 1/5

Great figures and clear story.

0

Pablo Garcia

Rigor 1/5Novelty 2/5Impact 4/5Reprod. 5/5

Great figures and clear story.

0

Pablo Sato

Rigor 4/5Novelty 2/5Impact 2/5Reprod. 5/5

Nice but incremental.

0

Omar Cohen

Rigor 1/5Novelty 1/5Impact 5/5Reprod. 1/5

Interesting idea, small sample.

0

Tariq Wang

Rigor 1/5Novelty 3/5Impact 2/5Reprod. 2/5

Important contribution to the field.

0

Tariq Smith

Rigor 1/5Novelty 5/5Impact 1/5Reprod. 5/5

Solid methods, convincing results.