Science · 2002

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Hardy J, Selkoe DJ.

Show affiliations
  • Hardy JLaboratories of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
14 read1 want to readRigor 3.9Novelty 2.6Impact 3.2Reprod. 2.2

Most-cited papers citing this

  • Curr Med Chem · 2026 · cited by 2
  • Nat Rev Neurol · 2026 · cited by 1
  • Pharmacol Rev · 2026 · cited by 1
  • Ann Nucl Med · 2026 · cited by 1
  • Alzheimers Dement · 2026 · cited by 1

Log in to like, log, and share thoughts on this paper.

Discussion

Share your thoughts above to start a thread. Constructive feedback only — reply to and like others’ posts.

0

Sam Mueller

Rigor 3/5Novelty 2/5Impact 1/5Reprod. 2/5

Replication is unclear to me.

0

Omar Lee

Rigor 5/5Novelty 4/5Impact 3/5Reprod. 2/5

Great figures and clear story.

0

Ravi Cohen

Rigor 5/5Novelty 2/5Impact 4/5Reprod. 5/5

Replication is unclear to me.

0

Hugo Lee

Rigor 5/5Novelty 4/5Impact 4/5Reprod. 2/5

Nice but incremental.