Cell Death Differ · 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

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Galluzzi L — Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA. deadoc@vodafone.it.
Vitale I — Department of Biology, University of Rome "Tor Vergata", Rome, Italy.
Aaronson SA — Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Abrams JM — Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Adam D — Institute of Immunology, Kiel University, Kiel, Germany.
Agostinis P — Cell Death Research & Therapy (CDRT) Lab, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.
Alnemri ES — Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Altucci L — Department of Biochemistry, Biophysics and General Pathology, University of Campania "Luigi Vanvitelli", Napoli, Italy.
Amelio I — Medical Research Council (MRC) Toxicology Unit, Leicester University, Leicester, UK.
Andrews DW — Biological Sciences, Sunnybrook Research Institute, Toronto, Canada.
Annicchiarico-Petruzzelli M — Biochemistry Laboratory, Dermopatic Institute of Immaculate (IDI) IRCCS, Rome, Italy.
Antonov AV — Medical Research Council (MRC) Toxicology Unit, Leicester University, Leicester, UK.
Arama E — Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Baehrecke EH — Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA.
Barlev NA — Institute of Cytology, Russian Academy of Sciences, Saint-Petersburg, Russia.
Bazan NG — Neuroscience Center of Excellence, Louisiana State University School of Medicine, New Orleans, LA, USA.
Bernassola F — Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
Bertrand MJM — VIB Center for Inflammation Research (IRC), Ghent, Belgium.
Bianchi K — Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Blagosklonny MV — Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Blomgren K — Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
Borner C — Institute of Molecular Medicine and Cell Research, Albert Ludwigs University, Freiburg, Germany.
Boya P — Department of Cellular and Molecular Biology, Center for Biological Investigation (CIB), Spanish National Research Council (CSIC), Madrid, Spain.
Brenner C — INSERM U1180, Châtenay Malabry, France.
Campanella M — Department of Biology, University of Rome "Tor Vergata", Rome, Italy.
Candi E — Biochemistry Laboratory, Dermopatic Institute of Immaculate (IDI) IRCCS, Rome, Italy.
Carmona-Gutierrez D — Department Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Cecconi F — Department of Biology, University of Rome "Tor Vergata", Rome, Italy.
Chan FK — Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Chandel NS — Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Cheng EH — Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Chipuk JE — Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cidlowski JA — Signal Transduction Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Ciechanover A — Technion Integrated Cancer Center (TICC), The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa, Israel.
Cohen GM — Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Conrad M — Institute of Developmental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health (GmbH), Munich, Germany.
Cubillos-Ruiz JR — Sandra and Edward Meyer Cancer Center, New York, NY, USA.
Czabotar PE — The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
D'Angiolella V — Cancer Research UK and Medical Research Council Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, UK.
Dawson TM — Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dawson VL — Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
De Laurenzi V — Department of Medical, Oral and Biotechnological Sciences, CeSI-MetUniversity of Chieti-Pescara "G. d'Annunzio", Chieti, Italy.
De Maria R — Institute of General Pathology, Catholic University "Sacro Cuore", Rome, Italy.
Debatin KM — Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
DeBerardinis RJ — Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Deshmukh M — Department of Cell Biology and Physiology, Neuroscience Center, University of North Carolina, Chapel Hill, NC, USA.
Di Daniele N — Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Di Virgilio F — Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Dixit VM — Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Dixon SJ — Department of Biology, Stanford University, Stanford, CA, USA.
Duckett CS — Baylor Scott & White Research Institute, Baylor College of Medicine, Dallas, TX, USA.
Dynlacht BD — Department of Pathology, New York University School of Medicine, New York, NY, USA.
El-Deiry WS — Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Elrod JW — Center for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine at Temple University School of Medicine, Philadelphia, PA, USA.
Fimia GM — National Institute for Infectious Diseases IRCCS "Lazzaro Spallanzani", Rome, Italy.
Fulda S — Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Frankfurt, Germany.
García-Sáez AJ — Interfaculty Institute of Biochemistry, Tübingen University, Tübingen, Germany.
Garg AD — Cell Death Research & Therapy (CDRT) Lab, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.
Garrido C — INSERM U1231 "Lipides Nutrition Cancer", Dijon, France.
Gavathiotis E — Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
Golstein P — Immunology Center of Marseille-Luminy, Aix Marseille University, Marseille, France.
Gottlieb E — Technion Integrated Cancer Center (TICC), The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa, Israel.
Green DR — Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Greene LA — Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Gronemeyer H — Team labeled "Ligue Contre le Cancer", Department of Functional Genomics and Cancer, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch, France.
Gross A — Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Hajnoczky G — MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Hardwick JM — Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Harris IS — Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Hengartner MO — Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Hetz C — Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.
Ichijo H — Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Jäättelä M — Cell Death and Metabolism Unit, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, Denmark.
Joseph B — Toxicology Unit, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Jost PJ — III Medical Department for Hematology and Oncology, Technical University Munich, Munich, Germany.
Juin PP — Team 8 "Stress adaptation and tumor escape", CRCINA-INSERM U1232, Nantes, France.
Kaiser WJ — Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center, San Antonio, TX, USA.
Karin M — Laboratory of Gene Regulation and Signal Transduction, University of California San Diego, La Jolla, CA, USA.
Kaufmann T — Institute of Pharmacology, University of Bern, Bern, Switzerland.
Kepp O — Paris Descartes/Paris V University, Paris, France.
Kimchi A — Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Kitsis RN — Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Klionsky DJ — Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Knight RA — Medical Research Council (MRC) Toxicology Unit, Leicester University, Leicester, UK.
Kumar S — Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia.
Lee SW — Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Lemasters JJ — Center for Cell Death, Injury and Regeneration, Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC, USA.
Levine B — Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Linkermann A — Division of Nephrology, University Hospital Carl Gustav Carus Dresden, Dresden, Germany.
Lipton SA — Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Lockshin RA — Department of Biology, St. John's University, Queens, NY, USA.
López-Otín C — Departament of Biochemistry and Molecular Biology, Faculty of Medicine, University Institute of Oncology of Asturias (IUOPA), University of Oviedo, Oviedo, Spain.
Lowe SW — Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.
Luedde T — Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, University Hospital RWTH Aachen, Aachen, Germany.
Lugli E — Laboratory of Translational Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
MacFarlane M — Medical Research Council (MRC) Toxicology Unit, Leicester University, Leicester, UK.
Madeo F — Department Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Malewicz M — Medical Research Council (MRC) Toxicology Unit, Leicester University, Leicester, UK.
Malorni W — National Centre for Gender Medicine, Italian National Institute of Health (ISS), Rome, Italy.
Manic G — Department of Biology, University of Rome "Tor Vergata", Rome, Italy.
Marine JC — Laboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, Leuven, Belgium.
Martin SJ — Departments of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland.
Martinou JC — Department of Cell Biology, Faculty of Sciences, University of Geneva, Geneva, Switzerland.
Medema JP — Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands.
Mehlen P — Apoptosis, Cancer and Development laboratory, CRCL, Lyon, France.
Meier P — The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building, Chester Beatty Laboratories, London, UK.
Melino S — Department of Chemical Sciences and Technologies, University of Rome, Tor Vergata, Rome, Italy.
Miao EA — Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA.
Molkentin JD — Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Moll UM — Department of Pathology, Stony Brook University, Stony Brook, NY, USA.
Muñoz-Pinedo C — Cell Death Regulation Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain.
Nagata S — Laboratory of Biochemistry and Immunology, World Premier International (WPI) Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.
Nuñez G — Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Oberst A — Department of Immunology, University of Washington, Seattle, WA, USA.
Oren M — Department of Molecular Cell Biology, Weizmann Institute, Rehovot, Israel.
Overholtzer M — Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Pagano M — Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA.
Panaretakis T — Department of Genitourinary Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Pasparakis M — Institute for Genetics, Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany.
Penninger JM — Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Campus Vienna BioCentre, Vienna, Austria.
Pereira DM — REQUIMTE/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Pervaiz S — Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Peter ME — Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Piacentini M — Department of Biology, University of Rome "Tor Vergata", Rome, Italy.
Pinton P — Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Prehn JHM — Department of Physiology, Royal College of Surgeons in Ireland, Dublin, Ireland.
Puthalakath H — Department of Biochemistry, La Trobe University, Victoria, Australia.
Rabinovich GA — Laboratory of Immunopathology, Institute of Biology and Experimental Medicine (IBYME), National Council of Scientific and Technical Research (CONICET), Buenos Aires, Argentina.
Rehm M — Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
Rizzuto R — Department of Biomedical Sciences, University of Padua, Padua, Italy.
Rodrigues CMP — Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal.
Rubinsztein DC — Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge, UK.
Rudel T — Department of Microbiology, Biocenter, University of Würzburg, Würzburg, Germany.
Ryan KM — Cancer Research UK Beatson Institute, Glasgow, UK.
Sayan E — Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Scorrano L — Department of Biology, University of Padua, Padua, Italy.
Shao F — National Institute of Biological Sciences, Beijing, China.
Shi Y — Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Chinese Academy of Sciences, Shanghai, China.
Silke J — Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.
Simon HU — Institute of Pharmacology, University of Bern, Bern, Switzerland.
Sistigu A — Institute of General Pathology, Catholic University "Sacro Cuore", Rome, Italy.
Stockwell BR — Department of Biological Sciences, Columbia University, New York, NY, USA.
Strasser A — The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Szabadkai G — Department of Biomedical Sciences, University of Padua, Padua, Italy.
Tait SWG — Cancer Research UK Beatson Institute, Glasgow, UK.
Tang D — The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Tavernarakis N — Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas Medical School, University of Crete, Heraklion, Greece.
Thorburn A — Department of Pharmacology, University of Colorado, Aurora, CO, USA.
Tsujimoto Y — Research Center, Osaka International Cancer Institute, Osaka, Japan.
Turk B — Department Biochemistry and Molecular Biology, "Jozef Stefan" Institute, Ljubljana, Slovenia.
Vanden Berghe T — VIB Center for Inflammation Research (IRC), Ghent, Belgium.
Vandenabeele P — VIB Center for Inflammation Research (IRC), Ghent, Belgium.
Vander Heiden MG — Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Villunger A — Division of Developmental Immunology, Innsbruck Medical University, Innsbruck, Austria.
Virgin HW — Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Vousden KH — Francis Crick Institute, London, UK.
Vucic D — Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA, USA.
Wagner EF — Genes, Development and Disease Group, Cancer Cell Biology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Walczak H — Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK.
Wallach D — Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Wang Y — Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Wells JA — Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Wood W — School of Cellular and Molecular Medicine, Faculty of Biomedical Sciences, University of Bristol, Bristol, UK.
Yuan J — Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Zakeri Z — Department of Biology, Queens College of the City University of New York, Queens, NY, USA.
Zhivotovsky B — Toxicology Unit, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Zitvogel L — Faculty of Medicine, Paris Sud/Paris XI University, Kremlin-Bicêtre, France.
Melino G — Medical Research Council (MRC) Toxicology Unit, Leicester University, Leicester, UK.
Kroemer G — Paris Descartes/Paris V University, Paris, France. kroemer@orange.fr.