Science · 2018

Coactivator condensation at super-enhancers links phase separation and gene control

Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, Malik S, Hnisz D, Lee TI, Cisse II, Roeder RG, Sharp PA, Chakraborty AK, Young RA.

Show affiliations
  • Sabari BRWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Dall'Agnese AWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Boija AWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Klein IAWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Coffey ELWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Shrinivas KDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Abraham BJWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Hannett NMWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Zamudio AVWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Manteiga JCWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Li CHWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Guo YEWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Day DSWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Schuijers JWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Vasile EKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Malik SLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.
  • Hnisz DWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Lee TIWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Cisse IIDepartment of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Roeder RGLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.
  • Sharp PADepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Chakraborty AKDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Young RAWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA. young@wi.mit.edu.
65 read8 want to readRigor 2.7Novelty 2.9Impact 2.9Reprod. 2.9

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Discussion

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0

Hugo Sato

Rigor 1/5Novelty 3/5Impact 4/5Reprod. 3/5

Interesting idea, small sample.

0

Omar Brown

Rigor 4/5Novelty 2/5Impact 4/5Reprod. 3/5

Interesting idea, small sample.

0

Sam Brown

Rigor 3/5Novelty 1/5Impact 3/5Reprod. 5/5

Solid methods, convincing results.

0

Ken Silva

Rigor 2/5Novelty 4/5Impact 2/5Reprod. 1/5

Replication is unclear to me.

0

Noor Cohen

Rigor 2/5Novelty 4/5Impact 5/5Reprod. 3/5

Replication is unclear to me.

0

Liam Park

Rigor 3/5Novelty 4/5Impact 1/5Reprod. 3/5

Important contribution to the field.

0

Lena Park

Rigor 2/5Novelty 1/5Impact 2/5Reprod. 4/5

Interesting idea, small sample.

0

Maya Lee

Rigor 1/5Novelty 2/5Impact 5/5Reprod. 5/5

Solid methods, convincing results.

0

Sam Garcia

Rigor 1/5Novelty 2/5Impact 1/5Reprod. 3/5

Nice but incremental.

0

Jonas Brown

Rigor 1/5Novelty 4/5Impact 5/5Reprod. 4/5

Nice but incremental.

0

Sara Rossi

Rigor 5/5Novelty 5/5Impact 5/5Reprod. 2/5

Solid methods, convincing results.

0

Tariq Sato

Rigor 1/5Novelty 4/5Impact 2/5Reprod. 2/5

Nice but incremental.

0

Liam Nguyen

Rigor 2/5Novelty 5/5Impact 4/5Reprod. 5/5

Important contribution to the field.

0

Jonas Nguyen

Rigor 4/5Novelty 3/5Impact 1/5Reprod. 3/5

Interesting idea, small sample.

0

Liam Cohen

Rigor 3/5Novelty 5/5Impact 1/5Reprod. 4/5

Nice but incremental.

0

Lena Kim

Rigor 1/5Novelty 2/5Impact 5/5Reprod. 2/5

Solid methods, convincing results.

0

Ken Garcia

Rigor 1/5Novelty 5/5Impact 5/5Reprod. 2/5

Important contribution to the field.

0

Alex Mueller

Rigor 3/5Novelty 3/5Impact 3/5Reprod. 1/5

Nice but incremental.