Science · 2018

Coactivator condensation at super-enhancers links phase separation and gene control

Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, Malik S, Hnisz D, Lee TI, Cisse II, Roeder RG, Sharp PA, Chakraborty AK, Young RA.

Show affiliations
  • Sabari BR — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Dall'Agnese A — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Boija A — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Klein IA — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Coffey EL — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Shrinivas K — Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Abraham BJ — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Hannett NM — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Zamudio AV — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Manteiga JC — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Li CH — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Guo YE — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Day DS — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Schuijers J — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Vasile E — Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Malik S — Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.
  • Hnisz D — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Lee TI — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Cisse II — Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Roeder RG — Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.
  • Sharp PA — Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Chakraborty AK — Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Young RA — Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA. young@wi.mit.edu.
65 read8 want to readRigor 2.7Novelty 2.9Impact 2.9Reprod. 2.9

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Discussion

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0

Hugo Sato

Rigor 1/5Novelty 3/5Impact 4/5Reprod. 3/5

Interesting idea, small sample.

0

Omar Brown

Rigor 4/5Novelty 2/5Impact 4/5Reprod. 3/5

Interesting idea, small sample.

0

Sam Brown

Rigor 3/5Novelty 1/5Impact 3/5Reprod. 5/5

Solid methods, convincing results.

0

Ken Silva

Rigor 2/5Novelty 4/5Impact 2/5Reprod. 1/5

Replication is unclear to me.

0

Noor Cohen

Rigor 2/5Novelty 4/5Impact 5/5Reprod. 3/5

Replication is unclear to me.

0

Liam Park

Rigor 3/5Novelty 4/5Impact 1/5Reprod. 3/5

Important contribution to the field.

0

Lena Park

Rigor 2/5Novelty 1/5Impact 2/5Reprod. 4/5

Interesting idea, small sample.

0

Maya Lee

Rigor 1/5Novelty 2/5Impact 5/5Reprod. 5/5

Solid methods, convincing results.

0

Sam Garcia

Rigor 1/5Novelty 2/5Impact 1/5Reprod. 3/5

Nice but incremental.

0

Jonas Brown

Rigor 1/5Novelty 4/5Impact 5/5Reprod. 4/5

Nice but incremental.

0

Sara Rossi

Rigor 5/5Novelty 5/5Impact 5/5Reprod. 2/5

Solid methods, convincing results.

0

Tariq Sato

Rigor 1/5Novelty 4/5Impact 2/5Reprod. 2/5

Nice but incremental.

0

Liam Nguyen

Rigor 2/5Novelty 5/5Impact 4/5Reprod. 5/5

Important contribution to the field.

0

Jonas Nguyen

Rigor 4/5Novelty 3/5Impact 1/5Reprod. 3/5

Interesting idea, small sample.

0

Liam Cohen

Rigor 3/5Novelty 5/5Impact 1/5Reprod. 4/5

Nice but incremental.

0

Lena Kim

Rigor 1/5Novelty 2/5Impact 5/5Reprod. 2/5

Solid methods, convincing results.

0

Ken Garcia

Rigor 1/5Novelty 5/5Impact 5/5Reprod. 2/5

Important contribution to the field.

0

Alex Mueller

Rigor 3/5Novelty 3/5Impact 3/5Reprod. 1/5

Nice but incremental.