Nature · 2014

PD-1 blockade induces responses by inhibiting adaptive immune resistance

Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJ, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, West AN, Carmona M, Kivork C, Seja E, Cherry G, Gutierrez AJ, Grogan TR, Mateus C, Tomasic G, Glaspy JA, Emerson RO, Robins H, Pierce RH, Elashoff DA, Robert C, Ribas A.

Show affiliations
  • Tumeh PC1] University of California Los Angeles (UCLA), Los Angeles, California 90095, USA [2] Jonsson Comprehensive Cancer Center, Los Angeles, California 90095, USA.
  • Harview CLUniversity of California Los Angeles (UCLA), Los Angeles, California 90095, USA.
  • Yearley JHMerck &Co, Palo Alto, California 94304, USA.
  • Shintaku IPUniversity of California Los Angeles (UCLA), Los Angeles, California 90095, USA.
  • Taylor EJUniversity of California Los Angeles (UCLA), Los Angeles, California 90095, USA.
  • Robert LUniversity of California Los Angeles (UCLA), Los Angeles, California 90095, USA.
  • Chmielowski B1] University of California Los Angeles (UCLA), Los Angeles, California 90095, USA [2] Jonsson Comprehensive Cancer Center, Los Angeles, California 90095, USA.
  • Spasic MUniversity of California Los Angeles (UCLA), Los Angeles, California 90095, USA.
  • Henry GUniversity of California Los Angeles (UCLA), Los Angeles, California 90095, USA.
  • Ciobanu VUniversity of California Los Angeles (UCLA), Los Angeles, California 90095, USA.
  • West ANUniversity of California Los Angeles (UCLA), Los Angeles, California 90095, USA.
  • Carmona MUniversity of California Los Angeles (UCLA), Los Angeles, California 90095, USA.
  • Kivork CUniversity of California Los Angeles (UCLA), Los Angeles, California 90095, USA.
  • Seja EUniversity of California Los Angeles (UCLA), Los Angeles, California 90095, USA.
  • Cherry GUniversity of California Los Angeles (UCLA), Los Angeles, California 90095, USA.
  • Gutierrez AJUniversity of California Los Angeles (UCLA), Los Angeles, California 90095, USA.
  • Grogan TRUniversity of California Los Angeles (UCLA), Los Angeles, California 90095, USA.
  • Mateus CGustave Roussy and INSERM U981, Villejuif, Paris Sud, France.
  • Tomasic GGustave Roussy and INSERM U981, Villejuif, Paris Sud, France.
  • Glaspy JA1] University of California Los Angeles (UCLA), Los Angeles, California 90095, USA [2] Jonsson Comprehensive Cancer Center, Los Angeles, California 90095, USA.
  • Emerson ROAdaptive Biotechnologies, Seattle, Washington 98102, USA.
  • Robins H1] Adaptive Biotechnologies, Seattle, Washington 98102, USA [2] Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Pierce RHMerck &Co, Palo Alto, California 94304, USA.
  • Elashoff DA1] University of California Los Angeles (UCLA), Los Angeles, California 90095, USA [2] Jonsson Comprehensive Cancer Center, Los Angeles, California 90095, USA.
  • Robert CGustave Roussy and INSERM U981, Villejuif, Paris Sud, France.
  • Ribas A1] University of California Los Angeles (UCLA), Los Angeles, California 90095, USA [2] Jonsson Comprehensive Cancer Center, Los Angeles, California 90095, USA.
49 read6 want to readRigor 2.9Novelty 2.9Impact 3.3Reprod. 3.3

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Discussion

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0

Alex Garcia

Rigor 5/5Novelty 4/5Impact 2/5Reprod. 4/5

Interesting idea, small sample.

0

Yuki Brown

Rigor 1/5Novelty 3/5Impact 1/5Reprod. 5/5

Great figures and clear story.

0

Liam Smith

Rigor 4/5Novelty 1/5Impact 2/5Reprod. 1/5

Great figures and clear story.

0

Tom Khan

Rigor 2/5Novelty 4/5Impact 5/5Reprod. 3/5

Great figures and clear story.

0

Ravi Khan

Rigor 5/5Novelty 4/5Impact 5/5Reprod. 1/5

Great figures and clear story.

0

Maya Cohen

Rigor 1/5Novelty 2/5Impact 3/5Reprod. 5/5

Replication is unclear to me.

0

Ken Cohen

Rigor 2/5Novelty 2/5Impact 4/5Reprod. 3/5

Interesting idea, small sample.

0

Ines Cohen

Rigor 1/5Novelty 1/5Impact 5/5Reprod. 2/5

Great figures and clear story.

0

Ines Wang

Rigor 3/5Novelty 4/5Impact 2/5Reprod. 2/5

Solid methods, convincing results.

0

Nadia Patel

Rigor 5/5Novelty 5/5Impact 3/5Reprod. 5/5

Solid methods, convincing results.

0

Ravi Lee

Rigor 2/5Novelty 4/5Impact 3/5Reprod. 2/5

Nice but incremental.