Cell · 2018

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

Boija A, Klein IA, Sabari BR, Dall'Agnese A, Coffey EL, Zamudio AV, Li CH, Shrinivas K, Manteiga JC, Hannett NM, Abraham BJ, Afeyan LK, Guo YE, Rimel JK, Fant CB, Schuijers J, Lee TI, Taatjes DJ, Young RA.

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Boija A — Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Klein IA — Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
Sabari BR — Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Dall'Agnese A — Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Coffey EL — Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Zamudio AV — Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Li CH — Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Shrinivas K — Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Manteiga JC — Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Hannett NM — Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Abraham BJ — Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Afeyan LK — Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Guo YE — Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Rimel JK — Department of Biochemistry, University of Colorado, Boulder, CO 80303, USA.
Fant CB — Department of Biochemistry, University of Colorado, Boulder, CO 80303, USA.
Schuijers J — Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Lee TI — Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Taatjes DJ — Department of Biochemistry, University of Colorado, Boulder, CO 80303, USA.
Young RA — Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: young@wi.mit.edu.