Nat Biotechnol · 2014

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

Fu Y, Sander JD, Reyon D, Cascio VM, Joung JK.

Show affiliations
  • Fu YMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.
  • Sander JDMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.
  • Reyon DMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.
  • Cascio VMMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.
  • Joung JKMolecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.
39 read6 want to readRigor 2.4Novelty 3.0Impact 3.0Reprod. 2.8

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0

Maya Park

Rigor 1/5Novelty 3/5Impact 5/5Reprod. 1/5

Great figures and clear story.

0

Ravi Kim

Rigor 2/5Novelty 4/5Impact 3/5Reprod. 2/5

Interesting idea, small sample.

0

Yuki Mueller

Rigor 4/5Novelty 4/5Impact 1/5Reprod. 3/5

Replication is unclear to me.

0

Tariq Lee

Rigor 2/5Novelty 1/5Impact 1/5Reprod. 1/5

Important contribution to the field.

0

Noor Sato

Rigor 3/5Novelty 4/5Impact 5/5Reprod. 5/5

Solid methods, convincing results.

0

Eva Nguyen

Rigor 3/5Novelty 2/5Impact 3/5Reprod. 3/5

Nice but incremental.

0

Maya Cohen

Rigor 1/5Novelty 3/5Impact 3/5Reprod. 1/5

Nice but incremental.

0

Tom Cohen

Rigor 3/5Novelty 1/5Impact 2/5Reprod. 1/5

Replication is unclear to me.

0

Pablo Patel

Rigor 1/5Novelty 5/5Impact 4/5Reprod. 1/5

Great figures and clear story.

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Sam Lee

Rigor 2/5Novelty 1/5Impact 5/5Reprod. 3/5

Nice but incremental.