Lancet Neurol · 2015

Neuroinflammation in Alzheimer's disease

Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP.

Show affiliations
  • Heneka MTDepartment of Neurology, University Hospital Bonn, University of Bonn, Bonn, Germany; German Center for Neurodegnerative Diseases (DZNE), Bonn, Germany. Electronic address: michael.heneka@ukb.uni-bonn.de.
  • Carson MJDivision of Biomedical Sciences, Center for Glial-Neuronal Interactions, University of California, Riverside, CA, USA.
  • El Khoury JDivision of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Landreth GEAlzheimer Research Laboratory, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Brosseron FGerman Center for Neurodegnerative Diseases (DZNE), Bonn, Germany.
  • Feinstein DLDepartment of Anesthesiology, University of Illinois, Chicago, IL, USA.
  • Jacobs AHDepartment of Geriatrics, Johanniter Hospital, Bonn, Germany; European Institute for Molecular Imaging (EIMI) at the Westfalian Wilhelms University (WWU), Münster, Germany.
  • Wyss-Coray TDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Center for Tissue Regeneration, Repair, and Restoration, VA Palo Alto Health Care System, Palo Alto, CA, USA.
  • Vitorica JInstituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocio, Consejo Superior de Investigaciones Cientificas Universidad de Sevilla, Sevilla, Spain.
  • Ransohoff RMDepartment of Neuroscience, Neuroinflammation Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Herrup KDivision of Life Science, Hong Kong University of Science and Technology, Hong Kong.
  • Frautschy SADepartment of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, the Geriatric, Research, and Clinical Center, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA, USA.
  • Finsen BInstitute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
  • Brown GCDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
  • Verkhratsky AFaculty of Life Sciences, The University of Manchester, Manchester, UK; Achucarro Center for Neuroscience, Basque Foundation for Science (IKERBASQUE), Bilbao, Spain; Department of Neurosciences, University of the Basque Country UPV/EHU (Euskal Herriko Unibertsitatea/Universidad del País Vasco) and CIBERNED (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas), Leioa, Spain.
  • Yamanaka KResearch Institute of Environmental Medicine, Nagoya University/RIKEN Brain Science Institute, Wako-shi, Japan.
  • Koistinaho JDepartment of Neurobiology, AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
  • Latz EGerman Center for Neurodegnerative Diseases (DZNE), Bonn, Germany; Institute of Innate Immunity, University of Bonn, Bonn, Germany; Department of InfectiousDiseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA.
  • Halle AMax-Planck Research Group Neuroimmunology, Center of Advanced European Studies and Research (CAESAR), Bonn, Germany.
  • Petzold GCDepartment of Neurology, University Hospital Bonn, University of Bonn, Bonn, Germany; German Center for Neurodegnerative Diseases (DZNE), Bonn, Germany.
  • Town TZilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
  • Morgan DDepartment of Molecular Pharmacology and Physiology, Byrd Alzheimer's Institute, University of South Florida College of Medicine, Tampa, FL, USA.
  • Shinohara MLDepartment of Immunology, Duke University Medical Center, Durham, NC, USA.
  • Perry VHSchool of Biological Sciences, Southampton General Hospital, Southampton, UK.
  • Holmes CClinical and Experimental Science, University of Southampton, Southampton, UK; Memory Assessment and Research Centre, Moorgreen Hospital, Southern Health Foundation Trust, Southampton, UK.
  • Bazan NGLouisiana State University Neuroscience Center of Excellence, Louisiana State University Health Sciences Center School of Medicine in New Orleans, LA, USA.
  • Brooks DJDivision of Experimental Medicine, Imperial College London, Hammersmith Hospital, London, UK.
  • Hunot SCentre National de la Recherche Scientifique (CNRS), UMR 7225, Experimental Therapeutics of Neurodegeneration, Paris, France.
  • Joseph BDepartment of Oncology Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden.
  • Deigendesch NDepartment of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany.
  • Garaschuk OInstitute of Physiology II, Eberhard Karls University of Tübingen, Tübingen, Germany.
  • Boddeke EDepartment of Neuroscience, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands.
  • Dinarello CADepartment of Medicine, University of Colorado Denver, Aurora, CO, USA.
  • Breitner JCCentre for Studies on Prevention of Alzheimer's Disease, Douglas Mental Health University Institute, and the McGill University Faculty of Medicine, Montreal, Quebec, Canada.
  • Cole GMDepartment of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, the Geriatric, Research, and Clinical Center, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA, USA.
  • Golenbock DTDepartment of InfectiousDiseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA.
  • Kummer MPDepartment of Neurology, University Hospital Bonn, University of Bonn, Bonn, Germany.
49 read10 want to readRigor 3.0Novelty 2.6Impact 3.2Reprod. 3.1

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0

Tariq Brown

Rigor 1/5Novelty 5/5Impact 4/5Reprod. 5/5

Solid methods, convincing results.

0

Mei Sato

Rigor 5/5Novelty 3/5Impact 5/5Reprod. 5/5

Nice but incremental.

0

Mei Silva

Rigor 1/5Novelty 2/5Impact 3/5Reprod. 4/5

Important contribution to the field.

0

Ken Silva

Rigor 1/5Novelty 1/5Impact 4/5Reprod. 1/5

Nice but incremental.

0

Yuki Silva

Rigor 4/5Novelty 2/5Impact 3/5Reprod. 4/5

Important contribution to the field.

0

Lena Cohen

Rigor 2/5Novelty 3/5Impact 5/5Reprod. 2/5

Replication is unclear to me.

0

Sam Mueller

Rigor 1/5Novelty 1/5Impact 4/5Reprod. 4/5

Interesting idea, small sample.

0

Alex Mueller

Rigor 2/5Novelty 5/5Impact 2/5Reprod. 5/5

Important contribution to the field.

0

Noor Khan

Rigor 1/5Novelty 5/5Impact 5/5Reprod. 5/5

Interesting idea, small sample.

0

Lena Rossi

Rigor 5/5Novelty 5/5Impact 4/5Reprod. 2/5

Nice but incremental.

0

Tariq Kim

Rigor 5/5Novelty 1/5Impact 2/5Reprod. 2/5

Important contribution to the field.

0

Sara Garcia

Rigor 5/5Novelty 5/5Impact 1/5Reprod. 3/5

Great figures and clear story.

0

Ravi Smith

Rigor 5/5Novelty 2/5Impact 2/5Reprod. 5/5

Great figures and clear story.