Nature · 2018

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Mariathasan S, Turley SJ, Nickles D, Castiglioni A, Yuen K, Wang Y, Kadel EE, Koeppen H, Astarita JL, Cubas R, Jhunjhunwala S, Banchereau R, Yang Y, Guan Y, Chalouni C, Ziai J, Şenbabaoğlu Y, Santoro S, Sheinson D, Hung J, Giltnane JM, Pierce AA, Mesh K, Lianoglou S, Riegler J, Carano RAD, Eriksson P, Höglund M, Somarriba L, Halligan DL, van der Heijden MS, Loriot Y, Rosenberg JE, Fong L, Mellman I, Chen DS, Green M, Derleth C, Fine GD, Hegde PS, Bourgon R, Powles T.

Show affiliations
  • Mariathasan S — Genentech, South San Francisco, California 94080, USA.
  • Turley SJ — Genentech, South San Francisco, California 94080, USA.
  • Nickles D — Genentech, South San Francisco, California 94080, USA.
  • Castiglioni A — Genentech, South San Francisco, California 94080, USA.
  • Yuen K — Genentech, South San Francisco, California 94080, USA.
  • Wang Y — Genentech, South San Francisco, California 94080, USA.
  • Kadel EE III — Genentech, South San Francisco, California 94080, USA.
  • Koeppen H — Genentech, South San Francisco, California 94080, USA.
  • Astarita JL — Genentech, South San Francisco, California 94080, USA.
  • Cubas R — Genentech, South San Francisco, California 94080, USA.
  • Jhunjhunwala S — Genentech, South San Francisco, California 94080, USA.
  • Banchereau R — Genentech, South San Francisco, California 94080, USA.
  • Yang Y — Genentech, South San Francisco, California 94080, USA.
  • Guan Y — Genentech, South San Francisco, California 94080, USA.
  • Chalouni C — Genentech, South San Francisco, California 94080, USA.
  • Ziai J — Genentech, South San Francisco, California 94080, USA.
  • Şenbabaoğlu Y — Genentech, South San Francisco, California 94080, USA.
  • Santoro S — Genentech, South San Francisco, California 94080, USA.
  • Sheinson D — Genentech, South San Francisco, California 94080, USA.
  • Hung J — Genentech, South San Francisco, California 94080, USA.
  • Giltnane JM — Genentech, South San Francisco, California 94080, USA.
  • Pierce AA — Genentech, South San Francisco, California 94080, USA.
  • Mesh K — Genentech, South San Francisco, California 94080, USA.
  • Lianoglou S — Genentech, South San Francisco, California 94080, USA.
  • Riegler J — Genentech, South San Francisco, California 94080, USA.
  • Carano RAD — Genentech, South San Francisco, California 94080, USA.
  • Eriksson P — Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Skåne 223 81, Sweden.
  • Höglund M — Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Skåne 223 81, Sweden.
  • Somarriba L — Fios Genomics, Edinburgh EH16 4UX, UK.
  • Halligan DL — Fios Genomics, Edinburgh EH16 4UX, UK.
  • van der Heijden MS — Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
  • Loriot Y — Department of Cancer Medicine, Institut Gustave Roussy, University of Paris Sud, 94800 Villejuif, France.
  • Rosenberg JE — Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
  • Fong L — University of California San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, California 94158, USA.
  • Mellman I — Genentech, South San Francisco, California 94080, USA.
  • Chen DS — Genentech, South San Francisco, California 94080, USA.
  • Green M — Genentech, South San Francisco, California 94080, USA.
  • Derleth C — Genentech, South San Francisco, California 94080, USA.
  • Fine GD — Genentech, South San Francisco, California 94080, USA.
  • Hegde PS — Genentech, South San Francisco, California 94080, USA.
  • Bourgon R — Genentech, South San Francisco, California 94080, USA.
  • Powles T — Barts Experimental Cancer Medicine Centre, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
Open on PubMed ↗Open at publisher ↗PMID 29443960
3 read1 want to readRigor 3.7Novelty 2.7Impact 3.3Reprod. 3.7

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Ravi Lee

Rigor 5/5Novelty 5/5Impact 4/5Reprod. 3/5

Great figures and clear story.