Genome Biol · 2014

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

Li W, Xu H, Xiao T, Cong L, Love MI, Zhang F, Irizarry RA, Liu JS, Brown M, Liu XS.

Show affiliations
  • Li W — Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, MA 02215 USA
  • Xu H — Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, MA 02215 USA
  • Xiao T — Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215 USA
  • Cong L — Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, MA 02142 USA
  • Love MI — Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, MA 02215 USA
  • Zhang F — Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142 USA
  • Irizarry RA — Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, MA 02215 USA
  • Liu JS — Department of Statistics, Harvard University, Science Center 715, 1 Oxford Street, Cambridge, MA 02138 USA
  • Brown M — Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215 USA
  • Liu XS — Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, MA 02215 USA
36 read3 want to readRigor 3.0Novelty 2.9Impact 2.9Reprod. 3.4

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Discussion

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0

Tariq Mueller

Rigor 4/5Novelty 3/5Impact 1/5Reprod. 3/5

Solid methods, convincing results.

0

Sam Garcia

Rigor 1/5Novelty 1/5Impact 2/5Reprod. 1/5

Nice but incremental.

0

Ken Sato

Rigor 3/5Novelty 2/5Impact 3/5Reprod. 4/5

Interesting idea, small sample.

0

Noor Brown

Rigor 1/5Novelty 2/5Impact 2/5Reprod. 4/5

Important contribution to the field.

0

Tariq Khan

Rigor 4/5Novelty 2/5Impact 2/5Reprod. 4/5

Replication is unclear to me.

0

Sam Park

Rigor 1/5Novelty 2/5Impact 1/5Reprod. 1/5

Important contribution to the field.

0

Noor Lee

Rigor 5/5Novelty 4/5Impact 3/5Reprod. 1/5

Replication is unclear to me.