Nature · 2014

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, Sosman JA, McDermott DF, Powderly JD, Gettinger SN, Kohrt HE, Horn L, Lawrence DP, Rost S, Leabman M, Xiao Y, Mokatrin A, Koeppen H, Hegde PS, Mellman I, Chen DS, Hodi FS.

Show affiliations
  • Herbst RSYale Comprehensive Cancer Center, Yale School of Medicine, 333 Cedar Street, WWW221, New Haven, Connecticut 06520, USA.
  • Soria JCGustave Roussy South-Paris University, 114 Rue Edouard Vaillant, 94805 Villefuij, Cedex, France.
  • Kowanetz MGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.
  • Fine GDGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.
  • Hamid OThe Angeles Clinic and Research Institute, 11818 Wilshire Blvd, Los Angeles, California 90025, USA.
  • Gordon MSPinnacle Oncology Hematology, 9055 E Del Camino Dr 100, Scottsdale, Arizona 85258, USA.
  • Sosman JAVanderbilt-Ingram Cancer Center, 2220 Pierce Avenue, Nashville, Tennessee 37212, USA.
  • McDermott DFBeth Israel Deaconess Medical Center, 330 Brookline Avenue, Shapiro 9, Boston, Massachusetts 02215, USA.
  • Powderly JDCarolina BioOncology Institute, 9801 W. Kincey Ave, Suite 145, Huntersville, North Carolina 28078, USA.
  • Gettinger SNYale Comprehensive Cancer Center, Yale School of Medicine, 333 Cedar Street, WWW221, New Haven, Connecticut 06520, USA.
  • Kohrt HEStanford University, CCSR Bldg Room 1110, Stanford, California 94305, USA.
  • Horn LVanderbilt-Ingram Cancer Center, 1301 Medical Center Dr, Suite 1710, Nashville, Tennessee 37212, USA.
  • Lawrence DPMassachusetts General Hospital, 55 Fruit Street, YAW 9E, Boston, Massachusetts 02114, USA.
  • Rost SGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.
  • Leabman MGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.
  • Xiao YGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.
  • Mokatrin AGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.
  • Koeppen HGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.
  • Hegde PSGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.
  • Mellman IGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.
  • Chen DSGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.
  • Hodi FSDana-Farber/Brigham and Women's Cancer Center, 450 Brookline Avenue, Boston, Massachusetts 02215, USA.
47 read11 want to readRigor 3.0Novelty 2.7Impact 2.7Reprod. 3.1

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Discussion

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0

Tom Khan

Rigor 3/5Novelty 1/5Impact 4/5Reprod. 4/5

Interesting idea, small sample.

0

Sam Rossi

Rigor 2/5Novelty 3/5Impact 1/5Reprod. 2/5

Great figures and clear story.

0

Lena Wang

Rigor 3/5Novelty 3/5Impact 2/5Reprod. 5/5

Interesting idea, small sample.

0

Tariq Patel

Rigor 3/5Novelty 5/5Impact 1/5Reprod. 3/5

Interesting idea, small sample.

0

Omar Brown

Rigor 2/5Novelty 5/5Impact 2/5Reprod. 3/5

Replication is unclear to me.

0

Jonas Khan

Rigor 4/5Novelty 1/5Impact 4/5Reprod. 3/5

Replication is unclear to me.

0

Hugo Cohen

Rigor 3/5Novelty 4/5Impact 3/5Reprod. 5/5

Nice but incremental.

0

Pablo Kim

Rigor 5/5Novelty 1/5Impact 4/5Reprod. 5/5

Replication is unclear to me.

0

Eva Wang

Rigor 3/5Novelty 2/5Impact 5/5Reprod. 2/5

Great figures and clear story.

0

Jonas Patel

Rigor 1/5Novelty 1/5Impact 1/5Reprod. 1/5

Interesting idea, small sample.