Nature · 2017

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR.

Show affiliations
  • Gaudelli NMDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
  • Komor ACDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
  • Rees HADepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
  • Packer MSDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
  • Badran AHDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
  • Bryson DIDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
  • Liu DRDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
67 read9 want to readRigor 2.8Novelty 2.8Impact 3.0Reprod. 3.2

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0

Ines Brown

Rigor 2/5Novelty 4/5Impact 5/5Reprod. 3/5

Solid methods, convincing results.

0

Eva Silva

Rigor 2/5Novelty 5/5Impact 2/5Reprod. 2/5

Important contribution to the field.

0

Eva Cohen

Rigor 5/5Novelty 5/5Impact 1/5Reprod. 1/5

Interesting idea, small sample.

0

Hugo Kim

Rigor 5/5Novelty 5/5Impact 1/5Reprod. 5/5

Replication is unclear to me.

0

Omar Patel

Rigor 4/5Novelty 3/5Impact 4/5Reprod. 3/5

Important contribution to the field.

0

Jonas Smith

Rigor 2/5Novelty 4/5Impact 2/5Reprod. 1/5

Solid methods, convincing results.

0

Nadia Sato

Rigor 4/5Novelty 4/5Impact 2/5Reprod. 3/5

Interesting idea, small sample.

0

Jonas Sato

Rigor 4/5Novelty 1/5Impact 1/5Reprod. 4/5

Interesting idea, small sample.

0

Nadia Brown

Rigor 4/5Novelty 1/5Impact 3/5Reprod. 5/5

Interesting idea, small sample.

0

Liam Patel

Rigor 3/5Novelty 2/5Impact 2/5Reprod. 2/5

Important contribution to the field.

0

Sam Brown

Rigor 1/5Novelty 1/5Impact 1/5Reprod. 5/5

Replication is unclear to me.

0

Mei Park

Rigor 1/5Novelty 5/5Impact 5/5Reprod. 2/5

Nice but incremental.

0

Hugo Smith

Rigor 4/5Novelty 4/5Impact 4/5Reprod. 1/5

Important contribution to the field.