Nature · 2013

Signatures of mutational processes in human cancer

Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, Bignell GR, Bolli N, Borg A, Børresen-Dale AL, Boyault S, Burkhardt B, Butler AP, Caldas C, Davies HR, Desmedt C, Eils R, Eyfjörd JE, Foekens JA, Greaves M, Hosoda F, Hutter B, Ilicic T, Imbeaud S, Imielinski M, Jäger N, Jones DT, Jones D, Knappskog S, Kool M, Lakhani SR, López-Otín C, Martin S, Munshi NC, Nakamura H, Northcott PA, Pajic M, Papaemmanuil E, Paradiso A, Pearson JV, Puente XS, Raine K, Ramakrishna M, Richardson AL, Richter J, Rosenstiel P, Schlesner M, Schumacher TN, Span PN, Teague JW, Totoki Y, Tutt AN, Valdés-Mas R, van Buuren MM, van 't Veer L, Vincent-Salomon A, Waddell N, Yates LR, Australian Pancreatic Cancer Genome Initiative, ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, ICGC PedBrain, Zucman-Rossi J, Futreal PA, McDermott U, Lichter P, Meyerson M, Grimmond SM, Siebert R, Campo E, Shibata T, Pfister SM, Campbell PJ, Stratton MR.

Show affiliations
  • Alexandrov LBCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.
10 read0 want to readRigor 3.4Novelty 3.3Impact 3.3Reprod. 3.3

Most-cited papers citing this

  • Nat Genet · 2026 · cited by 4
  • Nat Genet · 2026 · cited by 2
  • Nucleic Acids Res · 2026 · cited by 2
  • Sci Adv · 2025 · cited by 2
  • Nat Med · 2026 · cited by 1

Log in to like, log, and share thoughts on this paper.

Discussion

Share your thoughts above to start a thread. Constructive feedback only — reply to and like others’ posts.

0

Omar Sato

Rigor 4/5Novelty 2/5Impact 5/5Reprod. 2/5

Replication is unclear to me.

0

Maya Nguyen

Rigor 4/5Novelty 4/5Impact 4/5Reprod. 3/5

Replication is unclear to me.

0

Mei Garcia

Rigor 2/5Novelty 5/5Impact 2/5Reprod. 3/5

Interesting idea, small sample.

0

Liam Kim

Rigor 3/5Novelty 3/5Impact 4/5Reprod. 2/5

Interesting idea, small sample.

0

Pablo Silva

Rigor 2/5Novelty 5/5Impact 2/5Reprod. 5/5

Important contribution to the field.

0

Nadia Nguyen

Rigor 5/5Novelty 3/5Impact 5/5Reprod. 5/5

Nice but incremental.

0

Hugo Garcia

Rigor 3/5Novelty 2/5Impact 4/5Reprod. 2/5

Nice but incremental.