Cell · 2014

Generation of functional human pancreatic β cells in vitro

Pagliuca FW, Millman JR, Gürtler M, Segel M, Van Dervort A, Ryu JH, Peterson QP, Greiner D, Melton DA.

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  • Pagliuca FWDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.
  • Millman JRDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.
  • Gürtler MDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.
  • Segel MDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.
  • Van Dervort ADepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.
  • Ryu JHDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.
  • Peterson QPDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.
  • Greiner DDiabetes Center of Excellence, University of Massachusetts Medical School, 368 Plantation Street, AS7-2051, Worcester, MA 01605, USA.
  • Melton DADepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA. Electronic address: dmelton@harvard.edu.
58 read8 want to readRigor 3.2Novelty 2.9Impact 2.9Reprod. 2.8

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Discussion

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0

Nadia Sato

Rigor 3/5Novelty 3/5Impact 3/5Reprod. 3/5

Solid methods, convincing results.

0

Mei Park

Rigor 5/5Novelty 3/5Impact 5/5Reprod. 2/5

Solid methods, convincing results.

0

Pablo Smith

Rigor 3/5Novelty 3/5Impact 4/5Reprod. 4/5

Replication is unclear to me.

0

Tariq Patel

Rigor 4/5Novelty 2/5Impact 3/5Reprod. 2/5

Nice but incremental.

0

Liam Sato

Rigor 1/5Novelty 1/5Impact 4/5Reprod. 3/5

Nice but incremental.

0

Eva Rossi

Rigor 1/5Novelty 2/5Impact 4/5Reprod. 2/5

Great figures and clear story.

0

Yuki Kim

Rigor 4/5Novelty 3/5Impact 2/5Reprod. 4/5

Solid methods, convincing results.

0

Tom Mueller

Rigor 2/5Novelty 5/5Impact 1/5Reprod. 2/5

Interesting idea, small sample.

0

Alex Mueller

Rigor 5/5Novelty 5/5Impact 5/5Reprod. 3/5

Replication is unclear to me.

0

Nadia Wang

Rigor 1/5Novelty 5/5Impact 3/5Reprod. 5/5

Great figures and clear story.

0

Yuki Smith

Rigor 1/5Novelty 3/5Impact 5/5Reprod. 2/5

Great figures and clear story.

0

Lena Lee

Rigor 5/5Novelty 1/5Impact 2/5Reprod. 1/5

Important contribution to the field.

0

Ken Smith

Rigor 3/5Novelty 3/5Impact 2/5Reprod. 5/5

Important contribution to the field.