All read papers (48)
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
Chen JS, Ma E, Harrington LB, Da Costa M, Tian X, Palefsky JM, Doudna JA.
Science · 2018
Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial
El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C, Kim TY, Choo SP, Trojan J, Welling TH, Meyer T, Kang YK, Yeo W, Chopra A, Anderson J, Dela Cruz C, Lang L, Neely J, Tang H, Dastani HB, Melero I.
Lancet · 2017
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH.
Alzheimers Dement · 2011
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
Sikorski RS, Hieter P.
Genetics · 1989
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter
Melton DA, Krieg PA, Rebagliati MR, Maniatis T, Zinn K, Green MR.
Nucleic Acids Res · 1984
Elements of cancer immunity and the cancer-immune set point
Chen DS, Mellman I.
Nature · 2017
A comprehensive set of sequence analysis programs for the VAX
Devereux J, Haeberli P, Smithies O.
Nucleic Acids Res · 1984
An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association
Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, Elkind MS, George MG, Hamdan AD, Higashida RT, Hoh BL, Janis LS, Kase CS, Kleindorfer DO, Lee JM, Moseley ME, Peterson ED, Turan TN, Valderrama AL, Vinters HV, American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular and Stroke Nursing, Council on Epidemiology and Prevention, Council on Peripheral Vascular Disease, Council on Nutrition, Physical Activity and Metabolism.
Stroke · 2013
Differential expression analysis for sequence count data
Anders S, Huber W.
Genome Biol · 2010
The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2
Coronaviridae Study Group of the International Committee on Taxonomy of Viruses.
Nat Microbiol · 2020
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM.
Neuron · 2003
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ.
Nat Biotechnol · 2011
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, Tewari M.
Proc Natl Acad Sci U S A · 2008
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E.
Science · 2012
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G.
Nat Rev Neurol · 2013
Immune checkpoint blockade: a common denominator approach to cancer therapy
Topalian SL, Drake CG, Pardoll DM.
Cancer Cell · 2015
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA.
Cell · 2013
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis
Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I.
Mol Cell · 2017
The 2021 WHO Classification of Tumors of the Central Nervous System: a summary
Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW.
Neuro Oncol · 2021
DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants
Piñero J, Bravo À, Queralt-Rosinach N, Gutiérrez-Sacristán A, Deu-Pons J, Centeno E, García-García J, Sanz F, Furlong LI.
Nucleic Acids Res · 2017
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K, Lennon VA, Celis E, Chen L.
Nat Med · 2002
STAR: ultrafast universal RNA-seq aligner
Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M, Gingeras TR.
Bioinformatics · 2013
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M.
Proc Natl Acad Sci U S A · 1998
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergström M, Savitcheva I, Huang GF, Estrada S, Ausén B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Långström B.
Ann Neurol · 2004
Alzheimer's disease
Querfurth HW, LaFerla FM.
N Engl J Med · 2010
A view on drug resistance in cancer
Vasan N, Baselga J, Hyman DM.
Nature · 2019
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EG, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Grossman M, Miller BL.
Brain · 2011
Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants
Makarova KS, Wolf YI, Iranzo J, Shmakov SA, Alkhnbashi OS, Brouns SJJ, Charpentier E, Cheng D, Haft DH, Horvath P, Moineau S, Mojica FJM, Scott D, Shah SA, Siksnys V, Terns MP, Venclovas Č, White MF, Yakunin AF, Yan W, Zhang F, Garrett RA, Backofen R, van der Oost J, Barrangou R, Koonin EV.
Nat Rev Microbiol · 2020
IL-6 in inflammation, immunity, and disease
Tanaka T, Narazaki M, Kishimoto T.
Cold Spring Harb Perspect Biol · 2014
Non-coding RNA networks in cancer
Anastasiadou E, Jacob LS, Slack FJ.
Nat Rev Cancer · 2018
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation
Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, Vassar R.
J Neurosci · 2006
Integrated analysis of multimodal single-cell data
Hao Y, Hao S, Andersen-Nissen E, Mauck WM, Zheng S, Butler A, Lee MJ, Wilk AJ, Darby C, Zager M, Hoffman P, Stoeckius M, Papalexi E, Mimitou EP, Jain J, Srivastava A, Stuart T, Fleming LM, Yeung B, Rogers AJ, McElrath JM, Blish CA, Gottardo R, Smibert P, Satija R.
Cell · 2021
Role of the microbiota in immunity and inflammation
Belkaid Y, Hand TW.
Cell · 2014
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G.
Science · 1996
CRISPR-Cas systems for editing, regulating and targeting genomes
Sander JD, Joung JK.
Nat Biotechnol · 2014
RNA-programmed genome editing in human cells
Jinek M, East A, Cheng A, Lin S, Ma E, Doudna J.
Elife · 2013
A scaling normalization method for differential expression analysis of RNA-seq data
Robinson MD, Oshlack A.
Genome Biol · 2010
TREM2 variants in Alzheimer's disease
Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A, Hardy J, Alzheimer Genetic Analysis Group.
N Engl J Med · 2013
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR.
Nature · 2016
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J.
Nature · 2000
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B.
Science · 2016
SCENIC: single-cell regulatory network inference and clustering
Aibar S, González-Blas CB, Moerman T, Huynh-Thu VA, Imrichova H, Hulselmans G, Rambow F, Marine JC, Geurts P, Aerts J, van den Oord J, Atak ZK, Wouters J, Aerts S.
Nat Methods · 2017
Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
Schreiber RD, Old LJ, Smyth MJ.
Science · 2011
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, Cahill DP, Nahed BV, Curry WT, Martuza RL, Louis DN, Rozenblatt-Rosen O, Suvà ML, Regev A, Bernstein BE.
Science · 2014
TopHat: discovering splice junctions with RNA-Seq
Trapnell C, Pachter L, Salzberg SL.
Bioinformatics · 2009
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
Tirosh I, Izar B, Prakadan SM, Wadsworth MH, Treacy D, Trombetta JJ, Rotem A, Rodman C, Lian C, Murphy G, Fallahi-Sichani M, Dutton-Regester K, Lin JR, Cohen O, Shah P, Lu D, Genshaft AS, Hughes TK, Ziegler CG, Kazer SW, Gaillard A, Kolb KE, Villani AC, Johannessen CM, Andreev AY, Van Allen EM, Bertagnolli M, Sorger PK, Sullivan RJ, Flaherty KT, Frederick DT, Jané-Valbuena J, Yoon CH, Rozenblatt-Rosen O, Shalek AK, Regev A, Garraway LA.
Science · 2016
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L.
Neurology · 1991
A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease
Jessen F, Amariglio RE, van Boxtel M, Breteler M, Ceccaldi M, Chételat G, Dubois B, Dufouil C, Ellis KA, van der Flier WM, Glodzik L, van Harten AC, de Leon MJ, McHugh P, Mielke MM, Molinuevo JL, Mosconi L, Osorio RS, Perrotin A, Petersen RC, Rabin LA, Rami L, Reisberg B, Rentz DM, Sachdev PS, de la Sayette V, Saykin AJ, Scheltens P, Shulman MB, Slavin MJ, Sperling RA, Stewart R, Uspenskaya O, Vellas B, Visser PJ, Wagner M, Subjective Cognitive Decline Initiative (SCD-I) Working Group.
Alzheimers Dement · 2014