All read papers (48)
Differential expression analysis for sequence count data
Anders S, Huber W.
Genome Biol · 2010
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
Doench JG, Fusi N, Sullender M, Hegde M, Vaimberg EW, Donovan KF, Smith I, Tothova Z, Wilen C, Orchard R, Virgin HW, Listgarten J, Root DE.
Nat Biotechnol · 2016
Global prevalence of dementia: a Delphi consensus study
Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M, Alzheimer's Disease International.
Lancet · 2005
Efficient genome editing in zebrafish using a CRISPR-Cas system
Hwang WY, Fu Y, Reyon D, Maeder ML, Tsai SQ, Sander JD, Peterson RT, Yeh JR, Joung JK.
Nat Biotechnol · 2013
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions
Oughtred R, Rust J, Chang C, Breitkreutz BJ, Stark C, Willems A, Boucher L, Leung G, Kolas N, Zhang F, Dolma S, Coulombe-Huntington J, Chatr-Aryamontri A, Dolinski K, Tyers M.
Protein Sci · 2021
A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?
Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP.
Cell · 2011
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
Haass C, Selkoe DJ.
Nat Rev Mol Cell Biol · 2007
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
Cancer Genome Atlas Research Network.
Nature · 2008
The blockade of immune checkpoints in cancer immunotherapy
Pardoll DM.
Nat Rev Cancer · 2012
RNA-Seq: a revolutionary tool for transcriptomics
Wang Z, Gerstein M, Snyder M.
Nat Rev Genet · 2009
Genetic screens in human cells using the CRISPR-Cas9 system
Wang T, Wei JJ, Sabatini DM, Lander ES.
Science · 2014
Spatial reconstruction of single-cell gene expression data
Satija R, Farrell JA, Gennert D, Schier AF, Regev A.
Nat Biotechnol · 2015
A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data
Li H.
Bioinformatics · 2011
Diversity of the human intestinal microbial flora
Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA.
Science · 2005
Sphingolipids and their metabolism in physiology and disease
Hannun YA, Obeid LM.
Nat Rev Mol Cell Biol · 2018
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, Brayne C, Burns A, Cohen-Mansfield J, Cooper C, Costafreda SG, Dias A, Fox N, Gitlin LN, Howard R, Kales HC, Kivimäki M, Larson EB, Ogunniyi A, Orgeta V, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbæk G, Teri L, Mukadam N.
Lancet · 2020
De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis
Haas BJ, Papanicolaou A, Yassour M, Grabherr M, Blood PD, Bowden J, Couger MB, Eccles D, Li B, Lieber M, MacManes MD, Ott M, Orvis J, Pochet N, Strozzi F, Weeks N, Westerman R, William T, Dewey CN, Henschel R, LeDuc RD, Friedman N, Regev A.
Nat Protoc · 2013
Genome editing. The new frontier of genome engineering with CRISPR-Cas9
Doudna JA, Charpentier E.
Science · 2014
Gene regulation by long non-coding RNAs and its biological functions
Statello L, Guo CJ, Chen LL, Huarte M.
Nat Rev Mol Cell Biol · 2021
An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management
Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, Lynch DA, Ryu JH, Swigris JJ, Wells AU, Ancochea J, Bouros D, Carvalho C, Costabel U, Ebina M, Hansell DM, Johkoh T, Kim DS, King TE, Kondoh Y, Myers J, Müller NL, Nicholson AG, Richeldi L, Selman M, Dudden RF, Griss BS, Protzko SL, Schünemann HJ, ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis.
Am J Respir Crit Care Med · 2011
Alzheimer's disease: the amyloid cascade hypothesis
Hardy JA, Higgins GA.
Science · 1992
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton JK, Matov A, Galeas J, Dhruv HD, Berens ME, Schreiber SL, McCormick F, McManus MT.
Nature · 2017
The Immune Landscape of Cancer
Thorsson V, Gibbs DL, Brown SD, Wolf D, Bortone DS, Ou Yang TH, Porta-Pardo E, Gao GF, Plaisier CL, Eddy JA, Ziv E, Culhane AC, Paull EO, Sivakumar IKA, Gentles AJ, Malhotra R, Farshidfar F, Colaprico A, Parker JS, Mose LE, Vo NS, Liu J, Liu Y, Rader J, Dhankani V, Reynolds SM, Bowlby R, Califano A, Cherniack AD, Anastassiou D, Bedognetti D, Mokrab Y, Newman AM, Rao A, Chen K, Krasnitz A, Hu H, Malta TM, Noushmehr H, Pedamallu CS, Bullman S, Ojesina AI, Lamb A, Zhou W, Shen H, Choueiri TK, Weinstein JN, Guinney J, Saltz J, Holt RA, Rabkin CS, Cancer Genome Atlas Research Network, Lazar AJ, Serody JS, Demicco EG, Disis ML, Vincent BG, Shmulevich I.
Immunity · 2018
Development and applications of CRISPR-Cas9 for genome engineering
Hsu PD, Lander ES, Zhang F.
Cell · 2014
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients
Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, Karpinets TV, Prieto PA, Vicente D, Hoffman K, Wei SC, Cogdill AP, Zhao L, Hudgens CW, Hutchinson DS, Manzo T, Petaccia de Macedo M, Cotechini T, Kumar T, Chen WS, Reddy SM, Szczepaniak Sloane R, Galloway-Pena J, Jiang H, Chen PL, Shpall EJ, Rezvani K, Alousi AM, Chemaly RF, Shelburne S, Vence LM, Okhuysen PC, Jensen VB, Swennes AG, McAllister F, Marcelo Riquelme Sanchez E, Zhang Y, Le Chatelier E, Zitvogel L, Pons N, Austin-Breneman JL, Haydu LE, Burton EM, Gardner JM, Sirmans E, Hu J, Lazar AJ, Tsujikawa T, Diab A, Tawbi H, Glitza IC, Hwu WJ, Patel SP, Woodman SE, Amaria RN, Davies MA, Gershenwald JE, Hwu P, Lee JE, Zhang J, Coussens LM, Cooper ZA, Futreal PA, Daniel CR, Ajami NJ, Petrosino JF, Tetzlaff MT, Sharma P, Allison JP, Jenq RR, Wargo JA.
Science · 2018
Multi-omics approaches to disease
Hasin Y, Seldin M, Lusis A.
Genome Biol · 2017
Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains
Boija A, Klein IA, Sabari BR, Dall'Agnese A, Coffey EL, Zamudio AV, Li CH, Shrinivas K, Manteiga JC, Hannett NM, Abraham BJ, Afeyan LK, Guo YE, Rimel JK, Fant CB, Schuijers J, Lee TI, Taatjes DJ, Young RA.
Cell · 2018
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
Zlokovic BV.
Nat Rev Neurosci · 2011
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, Skora AD, Luber BS, Azad NS, Laheru D, Biedrzycki B, Donehower RC, Zaheer A, Fisher GA, Crocenzi TS, Lee JJ, Duffy SM, Goldberg RM, de la Chapelle A, Koshiji M, Bhaijee F, Huebner T, Hruban RH, Wood LD, Cuka N, Pardoll DM, Papadopoulos N, Kinzler KW, Zhou S, Cornish TC, Taube JM, Anders RA, Eshleman JR, Vogelstein B, Diaz LA.
N Engl J Med · 2015
A new coronavirus associated with human respiratory disease in China
Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, Hu Y, Tao ZW, Tian JH, Pei YY, Yuan ML, Zhang YL, Dai FH, Liu Y, Wang QM, Zheng JJ, Xu L, Holmes EC, Zhang YZ.
Nature · 2020
Extracellular vesicles: exosomes, microvesicles, and friends
Raposo G, Stoorvogel W.
J Cell Biol · 2013
Innate and adaptive immune cells in the tumor microenvironment
Gajewski TF, Schreiber H, Fu YX.
Nat Immunol · 2013
IL-6 in inflammation, immunity, and disease
Tanaka T, Narazaki M, Kishimoto T.
Cold Spring Harb Perspect Biol · 2014
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K.
Acta Neuropathol · 2006
Integrated analysis of multimodal single-cell data
Hao Y, Hao S, Andersen-Nissen E, Mauck WM, Zheng S, Butler A, Lee MJ, Wilk AJ, Darby C, Zager M, Hoffman P, Stoeckius M, Papalexi E, Mimitou EP, Jain J, Srivastava A, Stuart T, Fleming LM, Yeung B, Rogers AJ, McElrath JM, Blish CA, Gottardo R, Smibert P, Satija R.
Cell · 2021
Single-cell transcriptomic analysis of Alzheimer's disease
Mathys H, Davila-Velderrain J, Peng Z, Gao F, Mohammadi S, Young JZ, Menon M, He L, Abdurrob F, Jiang X, Martorell AJ, Ransohoff RM, Hafler BP, Bennett DA, Kellis M, Tsai LH.
Nature · 2019
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M.
Proc Natl Acad Sci U S A · 1998
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
Fu Y, Sander JD, Reyon D, Cascio VM, Joung JK.
Nat Biotechnol · 2014
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EG, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Grossman M, Miller BL.
Brain · 2011
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, Cerami E, Sander C, Schultz N.
Sci Signal · 2013
An integrated encyclopedia of DNA elements in the human genome
ENCODE Project Consortium.
Nature · 2012
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, Gräf S, Ha G, Haffari G, Bashashati A, Russell R, McKinney S, METABRIC Group, Langerød A, Green A, Provenzano E, Wishart G, Pinder S, Watson P, Markowetz F, Murphy L, Ellis I, Purushotham A, Børresen-Dale AL, Brenton JD, Tavaré S, Caldas C, Aparicio S.
Nature · 2012
Reactive astrocyte nomenclature, definitions, and future directions
Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A.
Nat Neurosci · 2021
RNA-programmed genome editing in human cells
Jinek M, East A, Cheng A, Lin S, Ma E, Doudna J.
Elife · 2013
A view on drug resistance in cancer
Vasan N, Baselga J, Hyman DM.
Nature · 2019
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
Kozak M.
Nucleic Acids Res · 1987
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β
Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M.
Sci Transl Med · 2012
Designing hydrogels for controlled drug delivery
Li J, Mooney DJ.
Nat Rev Mater · 2016