Sam Silva

All read papers (42)

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, Wang W, Song H, Huang B, Zhu N, Bi Y, Ma X, Zhan F, Wang L, Hu T, Zhou H, Hu Z, Zhou W, Zhao L, Chen J, Meng Y, Wang J, Lin Y, Yuan J, Xie Z, Ma J, Liu WJ, Wang D, Xu W, Holmes EC, Gao GF, Wu G, Chen W, Shi W, Tan W.

Lancet · 2020

3.3/5

An integrated encyclopedia of DNA elements in the human genome

ENCODE Project Consortium.

Nature · 2012

3.5/5

Alzheimer's disease

Blennow K, de Leon MJ, Zetterberg H.

Lancet · 2006

2.0/5

deepTools2: a next generation web server for deep-sequencing data analysis

Ramírez F, Ryan DP, Grüning B, Bhardwaj V, Kilpert F, Richter AS, Heyne S, Dündar F, Manke T.

Nucleic Acids Res · 2016

3.0/5

IL-6 in inflammation, immunity, and disease

Tanaka T, Narazaki M, Kishimoto T.

Cold Spring Harb Perspect Biol · 2014

4.5/5

Determining cell type abundance and expression from bulk tissues with digital cytometry

Newman AM, Steen CB, Liu CL, Gentles AJ, Chaudhuri AA, Scherer F, Khodadoust MS, Esfahani MS, Luca BA, Steiner D, Diehn M, Alizadeh AA.

Nat Biotechnol · 2019

2.8/5

Identification and characterization of essential genes in the human genome

Wang T, Birsoy K, Hughes NW, Krupczak KM, Post Y, Wei JJ, Lander ES, Sabatini DM.

Science · 2015

3.0/5

Easy quantitative assessment of genome editing by sequence trace decomposition

Brinkman EK, Chen T, Amendola M, van Steensel B.

Nucleic Acids Res · 2014

4.0/5

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

Yamamoto M, Kensler TW, Motohashi H.

Physiol Rev · 2018

3.5/5

Coactivator condensation at super-enhancers links phase separation and gene control

Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, Malik S, Hnisz D, Lee TI, Cisse II, Roeder RG, Sharp PA, Chakraborty AK, Young RA.

Science · 2018

2.0/5

Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

Sharma P, Hu-Lieskovan S, Wargo JA, Ribas A.

Cell · 2017

4.0/5

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

Fu Y, Foden JA, Khayter C, Maeder ML, Reyon D, Joung JK, Sander JD.

Nat Biotechnol · 2013

2.3/5

The blockade of immune checkpoints in cancer immunotherapy

Pardoll DM.

Nat Rev Cancer · 2012

1.8/5

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA.

Cell · 2013

3.3/5

Innate and adaptive immune cells in the tumor microenvironment

Gajewski TF, Schreiber H, Fu YX.

Nat Immunol · 2013

3.0/5

Ferroptosis: mechanisms, biology and role in disease

Jiang X, Jiang X, Stockwell BR, Conrad M.

Nat Rev Mol Cell Biol · 2021

2.5/5

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach

Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Trojanowski JQ, Vinters HV, Hyman BT, National Institute on Aging, Alzheimer’s Association.

Acta Neuropathol · 2012

3.0/5

CRISPResso2 provides accurate and rapid genome editing sequence analysis

Clement K, Rees H, Canver MC, Gehrke JM, Farouni R, Hsu JY, Cole MA, Liu DR, Joung JK, Bauer DE, Pinello L.

Nat Biotechnol · 2019

3.5/5

COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses

Shereen MA, Khan S, Kazmi A, Bashir N, Siddique R.

J Adv Res · 2020

2.8/5

Adeno-associated virus vector as a platform for gene therapy delivery

Wang D, Tai PWL, Gao G.

Nat Rev Drug Discov · 2019

4.0/5

Abiraterone and increased survival in metastatic prostate cancer

de Bono JS, Logothetis CJ, Molina A, Fizazi K, North S, Chu L, Chi KN, Jones RJ, Goodman OB, Saad F, Staffurth JN, Mainwaring P, Harland S, Flaig TW, Hutson TE, Cheng T, Patterson H, Hainsworth JD, Ryan CJ, Sternberg CN, Ellard SL, Fléchon A, Saleh M, Scholz M, Efstathiou E, Zivi A, Bianchini D, Loriot Y, Chieffo N, Kheoh T, Haqq CM, Scher HI, COU-AA-301 Investigators.

N Engl J Med · 2011

2.3/5

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

Leng F, Edison P.

Nat Rev Neurol · 2021

3.5/5

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

Gasiunas G, Barrangou R, Horvath P, Siksnys V.

Proc Natl Acad Sci U S A · 2012

3.5/5

A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease

Jessen F, Amariglio RE, van Boxtel M, Breteler M, Ceccaldi M, Chételat G, Dubois B, Dufouil C, Ellis KA, van der Flier WM, Glodzik L, van Harten AC, de Leon MJ, McHugh P, Mielke MM, Molinuevo JL, Mosconi L, Osorio RS, Perrotin A, Petersen RC, Rabin LA, Rami L, Reisberg B, Rentz DM, Sachdev PS, de la Sayette V, Saykin AJ, Scheltens P, Shulman MB, Slavin MJ, Sperling RA, Stewart R, Uspenskaya O, Vellas B, Visser PJ, Wagner M, Subjective Cognitive Decline Initiative (SCD-I) Working Group.

Alzheimers Dement · 2014

2.8/5

The Genotype-Tissue Expression (GTEx) project

GTEx Consortium.

Nat Genet · 2013

1.8/5

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, Klein WL.

Proc Natl Acad Sci U S A · 1998

2.5/5

Lipid nanoparticles for mRNA delivery

Hou X, Zaks T, Langer R, Dong Y.

Nat Rev Mater · 2021

4.3/5

The Immune Landscape of Cancer

Thorsson V, Gibbs DL, Brown SD, Wolf D, Bortone DS, Ou Yang TH, Porta-Pardo E, Gao GF, Plaisier CL, Eddy JA, Ziv E, Culhane AC, Paull EO, Sivakumar IKA, Gentles AJ, Malhotra R, Farshidfar F, Colaprico A, Parker JS, Mose LE, Vo NS, Liu J, Liu Y, Rader J, Dhankani V, Reynolds SM, Bowlby R, Califano A, Cherniack AD, Anastassiou D, Bedognetti D, Mokrab Y, Newman AM, Rao A, Chen K, Krasnitz A, Hu H, Malta TM, Noushmehr H, Pedamallu CS, Bullman S, Ojesina AI, Lamb A, Zhou W, Shen H, Choueiri TK, Weinstein JN, Guinney J, Saltz J, Holt RA, Rabkin CS, Cancer Genome Atlas Research Network, Lazar AJ, Serody JS, Demicco EG, Disis ML, Vincent BG, Shmulevich I.

Immunity · 2018

2.8/5

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer

Brahmer J, Reckamp KL, Baas P, Crinò L, Eberhardt WE, Poddubskaya E, Antonia S, Pluzanski A, Vokes EE, Holgado E, Waterhouse D, Ready N, Gainor J, Arén Frontera O, Havel L, Steins M, Garassino MC, Aerts JG, Domine M, Paz-Ares L, Reck M, Baudelet C, Harbison CT, Lestini B, Spigel DR.

N Engl J Med · 2015

2.5/5

Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion

Schreiber RD, Old LJ, Smyth MJ.

Science · 2011

3.5/5

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B.

Science · 2016

3.5/5

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, Heun R, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J.

Nat Genet · 2009

2.5/5

Defining a Cancer Dependency Map

Tsherniak A, Vazquez F, Montgomery PG, Weir BA, Kryukov G, Cowley GS, Gill S, Harrington WF, Pantel S, Krill-Burger JM, Meyers RM, Ali L, Goodale A, Lee Y, Jiang G, Hsiao J, Gerath WFJ, Howell S, Merkel E, Ghandi M, Garraway LA, Root DE, Golub TR, Boehm JS, Hahn WC.

Cell · 2017

3.0/5

Multiplex genome engineering using CRISPR/Cas systems

Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA, Zhang F.

Science · 2013

3.5/5

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MW, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuiness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Deniz Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F, European Alzheimer's Disease Initiative (EADI), Genetic and Environmental Risk in Alzheimer's Disease, Alzheimer's Disease Genetic Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology, Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannefelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltuenen M, Martin ER, Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina V, Seshadri S, Williams J, Schellenberg GD, Amouyel P.

Nat Genet · 2013

2.3/5

TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells

Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS, Li B, Liu XS.

Cancer Res · 2017

4.0/5

A framework for advancing our understanding of cancer-associated fibroblasts

Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z.

Nat Rev Cancer · 2020

3.5/5

A core gut microbiome in obese and lean twins

Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, Egholm M, Henrissat B, Heath AC, Knight R, Gordon JI.

Nature · 2009

3.3/5

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Cancer Genome Atlas Research Network.

Nature · 2008

2.5/5

Gene regulation by long non-coding RNAs and its biological functions

Statello L, Guo CJ, Chen LL, Huarte M.

Nat Rev Mol Cell Biol · 2021

1.5/5

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW.

Neuro Oncol · 2021

2.3/5

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

Doench JG, Fusi N, Sullender M, Hegde M, Vaimberg EW, Donovan KF, Smith I, Tothova Z, Wilen C, Orchard R, Virgin HW, Listgarten J, Root DE.

Nat Biotechnol · 2016

3.0/5