All read papers (61)
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach
Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Trojanowski JQ, Vinters HV, Hyman BT, National Institute on Aging, Alzheimer’s Association.
Acta Neuropathol · 2012
Generation of functional human pancreatic β cells in vitro
Pagliuca FW, Millman JR, Gürtler M, Segel M, Van Dervort A, Ryu JH, Peterson QP, Greiner D, Melton DA.
Cell · 2014
Super-enhancers in the control of cell identity and disease
Hnisz D, Abraham BJ, Lee TI, Lau A, Saint-André V, Sigova AA, Hoke HA, Young RA.
Cell · 2013
Integrated genomic analyses of ovarian carcinoma
Cancer Genome Atlas Research Network.
Nature · 2011
Spatial reconstruction of single-cell gene expression data
Satija R, Farrell JA, Gennert D, Schier AF, Regev A.
Nat Biotechnol · 2015
PD-1 and its ligands in tolerance and immunity
Keir ME, Butte MJ, Freeman GJ, Sharpe AH.
Annu Rev Immunol · 2008
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease
Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, Challis C, Schretter CE, Rocha S, Gradinaru V, Chesselet MF, Keshavarzian A, Shannon KM, Krajmalnik-Brown R, Wittung-Stafshede P, Knight R, Mazmanian SK.
Cell · 2016
RNA-Seq: a revolutionary tool for transcriptomics
Wang Z, Gerstein M, Snyder M.
Nat Rev Genet · 2009
Ferroptosis: mechanisms, biology and role in disease
Jiang X, Jiang X, Stockwell BR, Conrad M.
Nat Rev Mol Cell Biol · 2021
deepTools2: a next generation web server for deep-sequencing data analysis
Ramírez F, Ryan DP, Grüning B, Bhardwaj V, Kilpert F, Richter AS, Heyne S, Dündar F, Manke T.
Nucleic Acids Res · 2016
Alzheimer's disease is a synaptic failure
Selkoe DJ.
Science · 2002
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, Klein WL.
Proc Natl Acad Sci U S A · 1998
mTOR at the nexus of nutrition, growth, ageing and disease
Liu GY, Sabatini DM.
Nat Rev Mol Cell Biol · 2020
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD.
Proc Natl Acad Sci U S A · 1993
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G.
Science · 1996
The Human Cell Atlas
Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Göttgens B, Hacohen N, Haniffa M, Hemberg M, Kim S, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G, Pe'er D, Phillipakis A, Ponting CP, Quake S, Reik W, Rozenblatt-Rosen O, Sanes J, Satija R, Schumacher TN, Shalek A, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton M, Stubbington MJT, Theis FJ, Uhlen M, van Oudenaarden A, Wagner A, Watt F, Weissman J, Wold B, Xavier R, Yosef N, Human Cell Atlas Meeting Participants
eLife · 2017
Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains
Boija A, Klein IA, Sabari BR, Dall'Agnese A, Coffey EL, Zamudio AV, Li CH, Shrinivas K, Manteiga JC, Hannett NM, Abraham BJ, Afeyan LK, Guo YE, Rimel JK, Fant CB, Schuijers J, Lee TI, Taatjes DJ, Young RA.
Cell · 2018
A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster
Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, Xing F, Liu J, Yip CC, Poon RW, Tsoi HW, Lo SK, Chan KH, Poon VK, Chan WM, Ip JD, Cai JP, Cheng VC, Chen H, Hui CK, Yuen KY.
Lancet · 2020
Inferring tumour purity and stromal and immune cell admixture from expression data
Yoshihara K, Shahmoradgoli M, Martínez E, Vegesna R, Kim H, Torres-Garcia W, Treviño V, Shen H, Laird PW, Levine DA, Carter SL, Getz G, Stemke-Hale K, Mills GB, Verhaak RG.
Nat Commun · 2013
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EG, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Grossman M, Miller BL.
Brain · 2011
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K, Lennon VA, Celis E, Chen L.
Nat Med · 2002
Adeno-associated virus vector as a platform for gene therapy delivery
Wang D, Tai PWL, Gao G.
Nat Rev Drug Discov · 2019
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, Gräf S, Ha G, Haffari G, Bashashati A, Russell R, McKinney S, METABRIC Group, Langerød A, Green A, Provenzano E, Wishart G, Pinder S, Watson P, Markowetz F, Murphy L, Ellis I, Purushotham A, Børresen-Dale AL, Brenton JD, Tavaré S, Caldas C, Aparicio S.
Nature · 2012
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT.
Nature · 2013
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O'Brien JT, Barkhof F, Benavente OR, Black SE, Brayne C, Breteler M, Chabriat H, Decarli C, de Leeuw FE, Doubal F, Duering M, Fox NC, Greenberg S, Hachinski V, Kilimann I, Mok V, Oostenbrugge Rv, Pantoni L, Speck O, Stephan BC, Teipel S, Viswanathan A, Werring D, Chen C, Smith C, van Buchem M, Norrving B, Gorelick PB, Dichgans M, STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1).
Lancet Neurol · 2013
NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease
Jack CR, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Snyder HM, Sperling R, Contributors.
Alzheimers Dement · 2018
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis
Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I.
Mol Cell · 2017
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack CR, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ.
Lancet Neurol · 2010
A comprehensive set of sequence analysis programs for the VAX
Devereux J, Haeberli P, Smithies O.
Nucleic Acids Res · 1984
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ.
Nat Biotechnol · 2011
A scaling normalization method for differential expression analysis of RNA-seq data
Robinson MD, Oshlack A.
Genome Biol · 2010
The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH.
Alzheimers Dement · 2011
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Edgar R, Domrachev M, Lash AE.
Nucleic Acids Res · 2002
Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection
Eyquem J, Mansilla-Soto J, Giavridis T, van der Stegen SJ, Hamieh M, Cunanan KM, Odak A, Gönen M, Sadelain M.
Nature · 2017
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR, Pimentel H, Salzberg SL, Rinn JL, Pachter L.
Nat Protoc · 2012
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients
Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, Karpinets TV, Prieto PA, Vicente D, Hoffman K, Wei SC, Cogdill AP, Zhao L, Hudgens CW, Hutchinson DS, Manzo T, Petaccia de Macedo M, Cotechini T, Kumar T, Chen WS, Reddy SM, Szczepaniak Sloane R, Galloway-Pena J, Jiang H, Chen PL, Shpall EJ, Rezvani K, Alousi AM, Chemaly RF, Shelburne S, Vence LM, Okhuysen PC, Jensen VB, Swennes AG, McAllister F, Marcelo Riquelme Sanchez E, Zhang Y, Le Chatelier E, Zitvogel L, Pons N, Austin-Breneman JL, Haydu LE, Burton EM, Gardner JM, Sirmans E, Hu J, Lazar AJ, Tsujikawa T, Diab A, Tawbi H, Glitza IC, Hwu WJ, Patel SP, Woodman SE, Amaria RN, Davies MA, Gershenwald JE, Hwu P, Lee JE, Zhang J, Coussens LM, Cooper ZA, Futreal PA, Daniel CR, Ajami NJ, Petrosino JF, Tetzlaff MT, Sharma P, Allison JP, Jenq RR, Wargo JA.
Science · 2018
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love MI, Huber W, Anders S.
Genome Biol · 2014
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM.
Neuron · 2003
The blockade of immune checkpoints in cancer immunotherapy
Pardoll DM.
Nat Rev Cancer · 2012
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K.
Acta Neuropathol · 2006
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
Fu Y, Foden JA, Khayter C, Maeder ML, Reyon D, Joung JK, Sander JD.
Nat Biotechnol · 2013
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein
Glenner GG, Wong CW.
Biochem Biophys Res Commun · 1984
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
Sharma P, Hu-Lieskovan S, Wargo JA, Ribas A.
Cell · 2017
Engineering precision nanoparticles for drug delivery
Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R.
Nat Rev Drug Discov · 2021
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Langille MG, Zaneveld J, Caporaso JG, McDonald D, Knights D, Reyes JA, Clemente JC, Burkepile DE, Vega Thurber RL, Knight R, Beiko RG, Huttenhower C.
Nat Biotechnol · 2013
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
Zlokovic BV.
Nat Rev Neurosci · 2011
Elements of cancer immunity and the cancer-immune set point
Chen DS, Mellman I.
Nature · 2017
CRISPR-Cas systems for editing, regulating and targeting genomes
Sander JD, Joung JK.
Nat Biotechnol · 2014
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
Doench JG, Fusi N, Sullender M, Hegde M, Vaimberg EW, Donovan KF, Smith I, Tothova Z, Wilen C, Orchard R, Virgin HW, Listgarten J, Root DE.
Nat Biotechnol · 2016
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L.
Nature · 1991
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, Rogelj B, Ackerley S, Durnall JC, Williams KL, Buratti E, Baralle F, de Belleroche J, Mitchell JD, Leigh PN, Al-Chalabi A, Miller CC, Nicholson G, Shaw CE.
Science · 2008
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E.
Science · 2012
MicroRNA-23b regulates cellular architecture and impairs motogenic and invasive phenotypes during cancer progression
Pellegrino L, Krell J, Roca-Alonso L, Stebbing J, Castellano L.
Bioarchitecture · 2013
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system
Chen B, Gilbert LA, Cimini BA, Schnitzbauer J, Zhang W, Li GW, Park J, Blackburn EH, Weissman JS, Qi LS, Huang B.
Cell · 2013
DNA targeting specificity of RNA-guided Cas9 nucleases
Hsu PD, Scott DA, Weinstein JA, Ran FA, Konermann S, Agarwala V, Li Y, Fine EJ, Wu X, Shalem O, Cradick TJ, Marraffini LA, Bao G, Zhang F.
Nat Biotechnol · 2013
Functional Classification and Experimental Dissection of Long Noncoding RNAs
Kopp F, Mendell JT.
Cell · 2018
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, Nicholson AM, Finch NA, Flynn H, Adamson J, Kouri N, Wojtas A, Sengdy P, Hsiung GY, Karydas A, Seeley WW, Josephs KA, Coppola G, Geschwind DH, Wszolek ZK, Feldman H, Knopman DS, Petersen RC, Miller BL, Dickson DW, Boylan KB, Graff-Radford NR, Rademakers R.
Neuron · 2011
Efficient genome editing in zebrafish using a CRISPR-Cas system
Hwang WY, Fu Y, Reyon D, Maeder ML, Tsai SQ, Sander JD, Peterson RT, Yeh JR, Joung JK.
Nat Biotechnol · 2013
Immunity, inflammation, and cancer
Grivennikov SI, Greten FR, Karin M.
Cell · 2010
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
Long JM, Holtzman DM.
Cell · 2019
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
Kim D, Paggi JM, Park C, Bennett C, Salzberg SL.
Nat Biotechnol · 2019