All read papers (49)
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
Chen JS, Ma E, Harrington LB, Da Costa M, Tian X, Palefsky JM, Doudna JA.
Science · 2018
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
Chen EY, Tan CM, Kou Y, Duan Q, Wang Z, Meirelles GV, Clark NR, Ma'ayan A.
BMC Bioinformatics · 2013
Long Noncoding RNA and Cancer: A New Paradigm
Bhan A, Soleimani M, Mandal SS.
Cancer Res · 2017
Cluster analysis and display of genome-wide expression patterns
Eisen MB, Spellman PT, Brown PO, Botstein D.
Proc Natl Acad Sci U S A · 1998
Development and applications of CRISPR-Cas9 for genome engineering
Hsu PD, Lander ES, Zhang F.
Cell · 2014
Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors
Anzalone AV, Koblan LW, Liu DR.
Nat Biotechnol · 2020
Most mammalian mRNAs are conserved targets of microRNAs
Friedman RC, Farh KK, Burge CB, Bartel DP.
Genome Res · 2009
DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants
Piñero J, Bravo À, Queralt-Rosinach N, Gutiérrez-Sacristán A, Deu-Pons J, Centeno E, García-García J, Sanz F, Furlong LI.
Nucleic Acids Res · 2017
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, Wang W, Song H, Huang B, Zhu N, Bi Y, Ma X, Zhan F, Wang L, Hu T, Zhou H, Hu Z, Zhou W, Zhao L, Chen J, Meng Y, Wang J, Lin Y, Yuan J, Xie Z, Ma J, Liu WJ, Wang D, Xu W, Holmes EC, Gao GF, Wu G, Chen W, Shi W, Tan W.
Lancet · 2020
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack CR, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ.
Lancet Neurol · 2010
Genome engineering using the CRISPR-Cas9 system
Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F.
Nat Protoc · 2013
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
Haass C, Selkoe DJ.
Nat Rev Mol Cell Biol · 2007
Coactivator condensation at super-enhancers links phase separation and gene control
Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, Malik S, Hnisz D, Lee TI, Cisse II, Roeder RG, Sharp PA, Chakraborty AK, Young RA.
Science · 2018
DADA2: High-resolution sample inference from Illumina amplicon data
Callahan BJ, McMurdie PJ, Rosen MJ, Han AW, Johnson AJ, Holmes SP.
Nat Methods · 2016
The 2021 WHO Classification of Tumors of the Central Nervous System: a summary
Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW.
Neuro Oncol · 2021
Full-length transcriptome assembly from RNA-Seq data without a reference genome
Grabherr MG, Haas BJ, Yassour M, Levin JZ, Thompson DA, Amit I, Adiconis X, Fan L, Raychowdhury R, Zeng Q, Chen Z, Mauceli E, Hacohen N, Gnirke A, Rhind N, di Palma F, Birren BW, Nusbaum C, Lindblad-Toh K, Friedman N, Regev A.
Nat Biotechnol · 2011
RNA-guided human genome engineering via Cas9
Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, Norville JE, Church GM.
Science · 2013
A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data
Li H.
Bioinformatics · 2011
A Robust CRISPR/Cas9 System for Convenient, High-Efficiency Multiplex Genome Editing in Monocot and Dicot Plants
Ma X, Zhang Q, Zhu Q, Liu W, Chen Y, Qiu R, Wang B, Yang Z, Li H, Lin Y, Xie Y, Shen R, Chen S, Wang Z, Chen Y, Guo J, Chen L, Zhao X, Dong Z, Liu YG.
Mol Plant · 2015
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
Kim S, Kim D, Cho SW, Kim J, Kim JS.
Genome Res · 2014
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergström M, Savitcheva I, Huang GF, Estrada S, Ausén B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Långström B.
Ann Neurol · 2004
Metagenomic biomarker discovery and explanation
Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, Huttenhower C.
Genome Biol · 2011
Discovery and resupply of pharmacologically active plant-derived natural products: A review
Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger JM, Schuster D, Breuss JM, Bochkov V, Mihovilovic MD, Kopp B, Bauer R, Dirsch VM, Stuppner H.
Biotechnol Adv · 2015
Reactive astrocyte nomenclature, definitions, and future directions
Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A.
Nat Neurosci · 2021
Pathways towards and away from Alzheimer's disease
Mattson MP.
Nature · 2004
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
Fu Y, Foden JA, Khayter C, Maeder ML, Reyon D, Joung JK, Sander JD.
Nat Biotechnol · 2013
IL-6 in inflammation, immunity, and disease
Tanaka T, Narazaki M, Kishimoto T.
Cold Spring Harb Perspect Biol · 2014
Differential expression analysis for sequence count data
Anders S, Huber W.
Genome Biol · 2010
Phases of A beta-deposition in the human brain and its relevance for the development of AD
Thal DR, Rüb U, Orantes M, Braak H.
Neurology · 2002
Wnt signaling in cancer
Zhan T, Rindtorff N, Boutros M.
Oncogene · 2017
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
Sharma P, Hu-Lieskovan S, Wargo JA, Ribas A.
Cell · 2017
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM.
Neuron · 2003
Long COVID: major findings, mechanisms and recommendations
Davis HE, McCorkell L, Vogel JM, Topol EJ.
Nat Rev Microbiol · 2023
MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens
Li W, Xu H, Xiao T, Cong L, Love MI, Zhang F, Irizarry RA, Liu JS, Brown M, Liu XS.
Genome Biol · 2014
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, Cerami E, Sander C, Schultz N.
Sci Signal · 2013
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EG, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Grossman M, Miller BL.
Brain · 2011
A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster
Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, Xing F, Liu J, Yip CC, Poon RW, Tsoi HW, Lo SK, Chan KH, Poon VK, Chan WM, Ip JD, Cai JP, Cheng VC, Chen H, Hui CK, Yuen KY.
Lancet · 2020
Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
Sweeney MD, Sagare AP, Zlokovic BV.
Nat Rev Neurol · 2018
Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
Schreiber RD, Old LJ, Smyth MJ.
Science · 2011
Neuropathological stageing of Alzheimer-related changes
Braak H, Braak E.
Acta Neuropathol · 1991
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, Nicholson AM, Finch NA, Flynn H, Adamson J, Kouri N, Wojtas A, Sengdy P, Hsiung GY, Karydas A, Seeley WW, Josephs KA, Coppola G, Geschwind DH, Wszolek ZK, Feldman H, Knopman DS, Petersen RC, Miller BL, Dickson DW, Boylan KB, Graff-Radford NR, Rademakers R.
Neuron · 2011
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
Subramanian A, Narayan R, Corsello SM, Peck DD, Natoli TE, Lu X, Gould J, Davis JF, Tubelli AA, Asiedu JK, Lahr DL, Hirschman JE, Liu Z, Donahue M, Julian B, Khan M, Wadden D, Smith IC, Lam D, Liberzon A, Toder C, Bagul M, Orzechowski M, Enache OM, Piccioni F, Johnson SA, Lyons NJ, Berger AH, Shamji AF, Brooks AN, Vrcic A, Flynn C, Rosains J, Takeda DY, Hu R, Davison D, Lamb J, Ardlie K, Hogstrom L, Greenside P, Gray NS, Clemons PA, Silver S, Wu X, Zhao WN, Read-Button W, Wu X, Haggarty SJ, Ronco LV, Boehm JS, Schreiber SL, Doench JG, Bittker JA, Root DE, Wong B, Golub TR.
Cell · 2017
Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6
Gootenberg JS, Abudayyeh OO, Kellner MJ, Joung J, Collins JJ, Zhang F.
Science · 2018
The antibody aducanumab reduces Aβ plaques in Alzheimer's disease
Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A.
Nature · 2016
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, Fidelle M, Flament C, Poirier-Colame V, Opolon P, Klein C, Iribarren K, Mondragón L, Jacquelot N, Qu B, Ferrere G, Clémenson C, Mezquita L, Masip JR, Naltet C, Brosseau S, Kaderbhai C, Richard C, Rizvi H, Levenez F, Galleron N, Quinquis B, Pons N, Ryffel B, Minard-Colin V, Gonin P, Soria JC, Deutsch E, Loriot Y, Ghiringhelli F, Zalcman G, Goldwasser F, Escudier B, Hellmann MD, Eggermont A, Raoult D, Albiges L, Kroemer G, Zitvogel L.
Science · 2018
StringTie enables improved reconstruction of a transcriptome from RNA-seq reads
Pertea M, Pertea GM, Antonescu CM, Chang TC, Mendell JT, Salzberg SL.
Nat Biotechnol · 2015
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci L, Fabbri E.
Nat Rev Cardiol · 2018
Defining a Cancer Dependency Map
Tsherniak A, Vazquez F, Montgomery PG, Weir BA, Kryukov G, Cowley GS, Gill S, Harrington WF, Pantel S, Krill-Burger JM, Meyers RM, Ali L, Goodale A, Lee Y, Jiang G, Hsiao J, Gerath WFJ, Howell S, Merkel E, Ghandi M, Garraway LA, Root DE, Golub TR, Boehm JS, Hahn WC.
Cell · 2017
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
Ran FA, Hsu PD, Lin CY, Gootenberg JS, Konermann S, Trevino AE, Scott DA, Inoue A, Matoba S, Zhang Y, Zhang F.
Cell · 2013